Technology Process of 5-hydroxy-1,3-dimethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione
There total 4 articles about 5-hydroxy-1,3-dimethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 12h;
Reagent/catalyst;
Solvent;
Temperature;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 2-Picolinic acid; copper(l) iodide; caesium carbonate / 1,4-dioxane / 70 °C / Inert atmosphere; Sealed tube
2: sodium hydroxide; water / diethyl ether / 24 h / 20 °C
3: acetic acid; acetic anhydride; trifluoroacetic acid / chloroform / 4 h / 70 - 80 °C
4: dmap / N,N-dimethyl-formamide / 12 h / 20 °C
With
2-Picolinic acid; dmap; copper(l) iodide; water; acetic anhydride; caesium carbonate; acetic acid; trifluoroacetic acid; sodium hydroxide;
In
1,4-dioxane; diethyl ether; chloroform; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydroxide; water / diethyl ether / 24 h / 20 °C
2: acetic acid; acetic anhydride; trifluoroacetic acid / chloroform / 4 h / 70 - 80 °C
3: dmap / N,N-dimethyl-formamide / 12 h / 20 °C
With
dmap; water; acetic anhydride; acetic acid; trifluoroacetic acid; sodium hydroxide;
In
diethyl ether; chloroform; N,N-dimethyl-formamide;
