ethyl 2-((tert-butoxycarbonyloxy)(4-nitrophenyl)methyl)acrylate

Base Information

• Chemical Name: ethyl 2-((tert-butoxycarbonyloxy)(4-nitrophenyl)methyl)acrylate
• CAS No.: 944471-27-6
• Molecular Formula: C₁₇H₂₁NO₇
• Molecular Weight: 351.356
• Mol file: 944471-27-6.mol

Synonyms:ethyl 2-((tert-butoxycarbonyloxy)(4-nitrophenyl)methyl)acrylate

Chemical Property of ethyl 2-((tert-butoxycarbonyloxy)(4-nitrophenyl)methyl)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-((tert-butoxycarbonyloxy)(4-nitrophenyl)methyl)acrylate

There total 3 articles about ethyl 2-((tert-butoxycarbonyloxy)(4-nitrophenyl)methyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

di-tert-butyl dicarbonate (24424-99-5) + ethyl 2-(4-nitrohydroxybenzyl)acrylate (88039-47-8) → ethyl 2-((tert-butoxycarbonyloxy)(4-nitrophenyl)methyl)acrylate (944471-27-6)

Guidance literature:

With dmap; In benzene; for 1h; Heating;

DOI:10.1016/j.tet.2007.02.115

Reference yield:

4-nitrobenzaldehdye (555-16-8) → ethyl 2-((tert-butoxycarbonyloxy)(4-nitrophenyl)methyl)acrylate (944471-27-6)

Guidance literature:

Multi-step reaction with 2 steps

1: DABCO

2: 60 percent / DMAP / benzene / 1 h / Heating

With 1,4-diaza-bicyclo[2.2.2]octane; dmap; In benzene; 1: Baylis-Hillman reaction;

DOI:10.1016/j.tet.2007.02.115

Reference yield:

ethyl acrylate (140-88-5,9003-32-1) → ethyl 2-((tert-butoxycarbonyloxy)(4-nitrophenyl)methyl)acrylate (944471-27-6)

Guidance literature:

Multi-step reaction with 2 steps

1: DABCO

2: 60 percent / DMAP / benzene / 1 h / Heating

With 1,4-diaza-bicyclo[2.2.2]octane; dmap; In benzene; 1: Baylis-Hillman reaction;

DOI:10.1016/j.tet.2007.02.115

upstream raw materials:

di-tert-butyl dicarbonate

ethyl 2-(4-nitrohydroxybenzyl)acrylate

4-nitrobenzaldehdye

ethyl acrylate

Downstream raw materials:

(S)-tert-butyl 1-[(S)-2-(ethoxycarbonyl)-1-(4-nitrophenyl)allyl]-3-oxo-1,3-dihydroisobenzofuran-1-carboxylate

(R)-methyl 4-(1-(ethoxycarbonyl)vinyl)-3,3-dicyano-2-(4-fluorophenyl)-4-(4-nitrophenyl)cyclopent-1-enecarboxylate

(R)-methyl 4-(1-(ethoxycarbonyl)vinyl)-3,3-dicyano-4-(4-nitrophenyl)-2-p-tolylcyclopent-1-enecarboxylate

(R)-methyl 4-(1-(ethoxycarbonyl)vinyl)-3,3-dicyano-2-(3-methoxyphenyl)-4-(4-nitrophenyl)cyclopent-1-enecarboxylate