Technology Process of methyl 10-benzyl-11-oxo-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1c][1,4]benzodiazepine-8-carboxylate
There total 5 articles about methyl 10-benzyl-11-oxo-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1c][1,4]benzodiazepine-8-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 11-oxo-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-8-carboxylate;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 25 ℃;
Inert atmosphere;
Cooling with ice;
benzyl chloride;
In
N,N-dimethyl-formamide;
at 25 ℃;
for 1h;
Inert atmosphere;
DOI:10.1007/s11172-012-0166-7
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / acetonitrile / 2 h / 20 °C
2.1: ferrous(II) sulfate heptahydrate; hydrogenchloride; ammonium hydroxide / water; methanol / 0.42 h / 65 - 90 °C
3.1: acetic acid / 13 h / Reflux
4.1: sodium hydride / N,N-dimethyl-formamide / 25 °C / Inert atmosphere; Cooling with ice
4.2: 1 h / 25 °C / Inert atmosphere
With
hydrogenchloride; ferrous(II) sulfate heptahydrate; ammonium hydroxide; sodium hydride; triethylamine;
In
methanol; water; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1007/s11172-012-0166-7
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: ferrous(II) sulfate heptahydrate; hydrogenchloride; ammonium hydroxide / water; methanol / 0.42 h / 65 - 90 °C
2.1: acetic acid / 13 h / Reflux
3.1: sodium hydride / N,N-dimethyl-formamide / 25 °C / Inert atmosphere; Cooling with ice
3.2: 1 h / 25 °C / Inert atmosphere
With
hydrogenchloride; ferrous(II) sulfate heptahydrate; ammonium hydroxide; sodium hydride;
In
methanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1007/s11172-012-0166-7
![methyl 11-oxo-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-8-carboxylate](/Databaselist/images/loading.webp)
