1-(3-Cyclopropyl-2-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one

Base Information

Chemical Name:1-(3-Cyclopropyl-2-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one
CAS No.:1309832-06-1
Molecular Formula:C₁₁H₁₀FN₅O₃
Molecular Weight:279.231
Hs Code.:

Synonyms:1-(3-Cyclopropyl-2-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one

Suppliers and Price of 1-(3-Cyclopropyl-2-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one

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Chemical Property of 1-(3-Cyclopropyl-2-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one

Chemical Property:

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Technology Process of 1-(3-Cyclopropyl-2-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one

There total 4 articles about 1-(3-Cyclopropyl-2-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1104637-36-6
cyclopropylboronic acid methyliminodiacetic acid ester

: 1309832-05-0
1-(3-Bromo-2-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one

: 1309832-06-1
1-(3-Cyclopropyl-2-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one

Guidance literature:: With caesium carbonate; palladium diacetate; tricyclohexylphosphine; In water; toluene; at 100 ℃; Inert atmosphere;

Reference yield:

: 1309832-04-9
1-(3-Bromo-2-fluoro-5-nitrophenyl)-1H-tetrazol-5(4H)-one

: 1309832-06-1
1-(3-Cyclopropyl-2-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: caesium carbonate / tricyclohexylphosphine; palladium diacetate / toluene; water / 100 °C / Inert atmosphere

With potassium carbonate; caesium carbonate; palladium diacetate; tricyclohexylphosphine; In water; N,N-dimethyl-formamide; toluene; 2: Suzuki Coupling;

Reference yield:

: 1309833-32-6
3-bromo-2-fluoro-5-nitrobenzenamine

: 1309832-06-1
1-(3-Cyclopropyl-2-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 1 h / 100 °C

2: trimethylsilylazide / 100 °C

3: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4: caesium carbonate / tricyclohexylphosphine; palladium diacetate / toluene; water / 100 °C / Inert atmosphere

With trimethylsilylazide; potassium carbonate; caesium carbonate; palladium diacetate; tricyclohexylphosphine; In water; N,N-dimethyl-formamide; toluene; 4: Suzuki Coupling;