Technology Process of 3,3′-O,O-[(10RS,23RS)-10,23-dimethyldotriacontane-1,32-diyl]-bis(2-O-hexadecyl-sn-glycerol)
There total 1 articles about 3,3′-O,O-[(10RS,23RS)-10,23-dimethyldotriacontane-1,32-diyl]-bis(2-O-hexadecyl-sn-glycerol) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
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Multi-step reaction with 14 steps
1.1: sodium hydride / toluene / 8 h / Reflux
2.1: potassium hydroxide / water; ethanol / 8 h / Reflux
3.1: Isopropylbenzene; pyridine / 1 h / Reflux
4.1: lithium aluminium tetrahydride / diethyl ether / 6 h / Reflux
5.1: pyridinium p-toluenesulfonate / dichloromethane
6.1: dibromotriphenylphosphorane / dichloromethane / 20 °C
7.1: magnesium / diethyl ether / 3 h / Reflux
7.2: 3 h / -3 - 0 °C
8.1: triphenylphosphine; bromine / dichloromethane / 0 - 20 °C
9.1: potassium hydride / toluene / 18 h / 20 °C
9.2: 10 h / Reflux
10.1: methanol; pyridinium p-toluenesulfonate / 10 h / Reflux
11.1: di(n-butyl)tin oxide / methanol; toluene / 1 h / 20 °C / Molecular sieve; Reflux
11.2: 2.5 h / Molecular sieve; Reflux
12.1: potassium hydride / toluene / 20 h / 20 °C / Inert atmosphere
12.2: 12 h / Reflux; Inert atmosphere
13.1: Grubbs catalyst first generation / dichloromethane / 24 h / Inert atmosphere; Reflux
14.1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol; ethyl acetate / 18 h / 20 °C / 1520.1 Torr
With
pyridine; Grubbs catalyst first generation; methanol; lithium aluminium tetrahydride; Isopropylbenzene; 10 wt% Pd(OH)2 on carbon; hydrogen; bromine; pyridinium p-toluenesulfonate; potassium hydride; sodium hydride; di(n-butyl)tin oxide; magnesium; triphenylphosphine; potassium hydroxide; dibromotriphenylphosphorane;
In
methanol; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1039/c4ob00048j
