(7R,8S)-3-(3-methyl-1H-1,2,4-triazol-5-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-amine

Base Information

Chemical Name:(7R,8S)-3-(3-methyl-1H-1,2,4-triazol-5-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-amine
CAS No.:1610458-02-0
Molecular Formula:C₂₀H₁₇F₃N₆
Molecular Weight:398.39
Hs Code.:

Synonyms:(7R,8S)-3-(3-methyl-1H-1,2,4-triazol-5-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-amine

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Chemical Property of (7R,8S)-3-(3-methyl-1H-1,2,4-triazol-5-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-amine

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Technology Process of (7R,8S)-3-(3-methyl-1H-1,2,4-triazol-5-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-amine

There total 10 articles about (7R,8S)-3-(3-methyl-1H-1,2,4-triazol-5-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610458-25-7
tert-butyl ((7R,8S)-3-(3-methyl-1H-1,2,4-triazol-5-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

: 1610458-02-0
(7R,8S)-3-(3-methyl-1H-1,2,4-triazol-5-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-amine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 0 - 5 ℃; for 1h;

Reference yield:

: 1384126-46-8
2-bromo-4-nitro-5-(2,4,5-trifluorophenyl)cyclohexanone

: 1610458-02-0
(7R,8S)-3-(3-methyl-1H-1,2,4-triazol-5-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-amine

Guidance literature:: Multi-step reaction with 9 steps

1: 2-methyl-propan-1-ol / 5 h / -10 - 0 °C / Reflux

2: zinc; ammonium chloride; acetic acid / water; tetrahydrofuran / 2 h / 50 °C

3: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

4: hydrogenchloride / water / 24 h / 100 °C / pH 12

5: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide / 2.33 h / 0 - 20 °C

6: triethylamine / tetrahydrofuran / 20 °C

7: 1 h / Reflux

8: acetic acid; hydrazine hydrate / ethanol / 60 °C

9: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 5 °C

With hydrogenchloride; dihydrogen peroxide; potassium carbonate; ammonium chloride; benzotriazol-1-ol; hydrazine hydrate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; 1,4-dioxane; ethanol; 2-methyl-propan-1-ol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1384126-47-9
1,2,4-trifluoro-5-(3-methoxy-6-nitrocyclohex-3-enyl)benzene

: 1610458-02-0
(7R,8S)-3-(3-methyl-1H-1,2,4-triazol-5-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-amine

Guidance literature:: Multi-step reaction with 10 steps

1: N-Bromosuccinimide; sodium acetate / water; tetrahydrofuran / 0.5 h / 0 °C

2: 2-methyl-propan-1-ol / 5 h / -10 - 0 °C / Reflux

3: zinc; ammonium chloride; acetic acid / water; tetrahydrofuran / 2 h / 50 °C

4: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

5: hydrogenchloride / water / 24 h / 100 °C / pH 12

6: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide / 2.33 h / 0 - 20 °C

7: triethylamine / tetrahydrofuran / 20 °C

8: 1 h / Reflux

9: acetic acid; hydrazine hydrate / ethanol / 60 °C

10: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 5 °C

With hydrogenchloride; N-Bromosuccinimide; dihydrogen peroxide; sodium acetate; potassium carbonate; ammonium chloride; benzotriazol-1-ol; hydrazine hydrate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; 1,4-dioxane; ethanol; 2-methyl-propan-1-ol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;