[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2,5-dioxo-pyrrolidin-1-ylmethyl ester

Base Information

• Chemical Name: [1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2,5-dioxo-pyrrolidin-1-ylmethyl ester
• CAS No.: 1026091-18-8
• Molecular Formula: C₂₄H₂₁ClN₂O₆
• Molecular Weight: 468.894

Synonyms:[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2,5-dioxo-pyrrolidin-1-ylmethyl ester

Chemical Property of [1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2,5-dioxo-pyrrolidin-1-ylmethyl ester

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Technology Process of [1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2,5-dioxo-pyrrolidin-1-ylmethyl ester

There total 2 articles about [1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2,5-dioxo-pyrrolidin-1-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(Hydroxymethyl)succinimide (5146-68-9) + 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetyl chloride (20357-37-3) → [1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2,5-dioxo-pyrrolidin-1-ylmethyl ester (1026091-18-8)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 10h;

DOI:10.1016/S0223-5234(00)80025-2

Reference yield:

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid (53-86-1) → [1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2,5-dioxo-pyrrolidin-1-ylmethyl ester (1026091-18-8)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / benzene / 3 h / Heating

2: Et₃N; 4-dimethylaminopyridine / CH₂Cl₂ / 10 h / 20 °C

With dmap; thionyl chloride; triethylamine; In dichloromethane; benzene; 1: Substitution / 2: Substitution;

DOI:10.1016/S0223-5234(00)80025-2

Reference yield:

[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2,5-dioxo-pyrrolidin-1-ylmethyl ester (1026091-18-8) → [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid (53-86-1)

Guidance literature:

With Tween 80; potassium chloride; In phosphate buffer; at 37 ℃; pH=7.4; Further Variations:; pH-values; also in 80 percent human plasma or 10 percent rat liver homogenate; Kinetics;

DOI:10.1016/S0223-5234(00)80025-2

upstream raw materials:

N-(Hydroxymethyl)succinimide

1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetyl chloride

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Downstream raw materials:

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

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