(2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-fluorophenyl)methanesulfonic acid

Base Information

Chemical Name:(2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-fluorophenyl)methanesulfonic acid
CAS No.:1050595-98-6
Molecular Formula:C₂₂H₂₅ClFNO₆S
Molecular Weight:485.961
Hs Code.:

Synonyms:(2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-fluorophenyl)methanesulfonic acid

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Chemical Property of (2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-fluorophenyl)methanesulfonic acid

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Technology Process of (2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-fluorophenyl)methanesulfonic acid

There total 4 articles about (2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-fluorophenyl)methanesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₄Cl₂FNO₃

: 1050595-98-6
(2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-fluorophenyl)methanesulfonic acid

Guidance literature:: With sodium sulfite; In ethanol; water; at 80 ℃; for 18h;

Reference yield:

: 1050596-47-8
{4-fluoro-2-[(2S)-oxiran-2-ylmethoxy]phenyl}methanol

: 1050595-98-6
(2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-fluorophenyl)methanesulfonic acid

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 18 h / 80 °C

2: tetrachloromethane; triphenylphosphine / dichloromethane / 25 h / 20 °C

3: sodium sulfite / ethanol; water / 18 h / 80 °C

With tetrachloromethane; triphenylphosphine; sodium sulfite; In ethanol; dichloromethane; water;

Reference yield:

: 1050596-49-0
(2S)-1-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-3-[5-fluoro-2-(hydroxymethyl)phenoxy]propan-2-ol

: 1050595-98-6
(2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-fluorophenyl)methanesulfonic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetrachloromethane; triphenylphosphine / dichloromethane / 25 h / 20 °C

2: sodium sulfite / ethanol; water / 18 h / 80 °C

With tetrachloromethane; triphenylphosphine; sodium sulfite; In ethanol; dichloromethane; water;