trans-1-(4-methoxyphenyl)-3-phenoxy-4-methyl-4-(4-nitrophenylmethyl)thio-azetidin-2-one

Base Information

Chemical Name:trans-1-(4-methoxyphenyl)-3-phenoxy-4-methyl-4-(4-nitrophenylmethyl)thio-azetidin-2-one
CAS No.:137242-84-3
Molecular Formula:C₂₄H₂₂N₂O₅S
Molecular Weight:450.515
Hs Code.:

Synonyms:trans-1-(4-methoxyphenyl)-3-phenoxy-4-methyl-4-(4-nitrophenylmethyl)thio-azetidin-2-one

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Chemical Property of trans-1-(4-methoxyphenyl)-3-phenoxy-4-methyl-4-(4-nitrophenylmethyl)thio-azetidin-2-one

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Technology Process of trans-1-(4-methoxyphenyl)-3-phenoxy-4-methyl-4-(4-nitrophenylmethyl)thio-azetidin-2-one

There total 3 articles about trans-1-(4-methoxyphenyl)-3-phenoxy-4-methyl-4-(4-nitrophenylmethyl)thio-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 58613-67-5
potassium phenoxyacetate

: 137272-05-0
S-(4-nitrophenyl)methyl N-(4-methoxyphenyl)-acetthioimidate

: 137242-84-3
trans-1-(4-methoxyphenyl)-3-phenoxy-4-methyl-4-(4-nitrophenylmethyl)thio-azetidin-2-one

Guidance literature:: With O-phenyl phosphorodichloridate; triethylamine; In dichloromethane; 1) 0 deg C, 2 h, 2) rt, overnight;
DOI:10.1016/S0040-4020(01)82327-9

Reference yield:

: 5310-18-9
N-(4-methoxyphenyl)thioacetamide

: 137242-84-3
trans-1-(4-methoxyphenyl)-3-phenoxy-4-methyl-4-(4-nitrophenylmethyl)thio-azetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaH / 1) THF, 1 h, rt

2: 81 percent / Et₃N, phenyl dichlorophosphate / CH₂Cl₂ / 1) 0 deg C, 2 h, 2) rt, overnight

With sodium hydride; O-phenyl phosphorodichloridate; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4020(01)82327-9

Reference yield:

: 51-66-1
4-methoxyacetanilide

: 137242-84-3
trans-1-(4-methoxyphenyl)-3-phenoxy-4-methyl-4-(4-nitrophenylmethyl)thio-azetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / 2,4-bis-(p-methoxyphenyl)-1,3-dithiadiphosphetane-2,4-disulfide / hexamethylphosphoric acid triamide / 100 °C

2: 1) NaH / 1) THF, 1 h, rt

3: 81 percent / Et₃N, phenyl dichlorophosphate / CH₂Cl₂ / 1) 0 deg C, 2 h, 2) rt, overnight

With Lawessons reagent; sodium hydride; O-phenyl phosphorodichloridate; triethylamine; In N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1016/S0040-4020(01)82327-9