diethyl 1-(N-benzyl-4-methylphenylsulfonamido)-3-phenylbuta-1,2-dienylphosphonate

Base Information

• Chemical Name: diethyl 1-(N-benzyl-4-methylphenylsulfonamido)-3-phenylbuta-1,2-dienylphosphonate
• CAS No.: 1380066-28-3
• Molecular Formula: C₂₈H₃₂NO₅PS
• Molecular Weight: 525.606
• Mol file: 1380066-28-3.mol

Synonyms:diethyl 1-(N-benzyl-4-methylphenylsulfonamido)-3-phenylbuta-1,2-dienylphosphonate

Chemical Property of diethyl 1-(N-benzyl-4-methylphenylsulfonamido)-3-phenylbuta-1,2-dienylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of diethyl 1-(N-benzyl-4-methylphenylsulfonamido)-3-phenylbuta-1,2-dienylphosphonate

There total 1 articles about diethyl 1-(N-benzyl-4-methylphenylsulfonamido)-3-phenylbuta-1,2-dienylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyl-p-toluenesulfonamide (1576-37-0) + 4-bromo-2-phenyl-3-butyn-2-ol (70650-50-9) → diethyl 1-(N-benzyl-4-methylphenylsulfonamido)-3-phenylbuta-1,2-dienylphosphonate (1380066-28-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate; copper(ll) sulfate pentahydrate; 1,10-Phenanthroline / toluene / 70 °C / Inert atmosphere

2: triethylamine / diethyl ether / 0 - 20 °C / Inert atmosphere

With potassium phosphate; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; triethylamine; In diethyl ether; toluene;

DOI:10.1021/jo300790m

Reference yield: 45.0%

propylamine (107-10-8,42939-71-9) + diethyl 1-(N-benzyl-4-methylphenylsulfonamido)-3-phenylbuta-1,2-dienylphosphonate (1380066-28-3) → diethyl 2-phenyl-5-(1-phenylethyl)-1-propyl-1H-imidazol-4-ylphosphonate

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; regioselective reaction;

DOI:10.1021/acs.joc.5b00141

upstream raw materials:

N-benzyl-p-toluenesulfonamide

4-bromo-2-phenyl-3-butyn-2-ol