(R)-diethyl 2-(((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-fluoromalonate

Base Information

Chemical Name:(R)-diethyl 2-(((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-fluoromalonate
CAS No.:1236292-94-6
Molecular Formula:C₁₉H₂₆FNO₆
Molecular Weight:383.417
Hs Code.:

Synonyms:(R)-diethyl 2-(((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-fluoromalonate

Suppliers and Price of (R)-diethyl 2-(((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-fluoromalonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-diethyl 2-(((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-fluoromalonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-diethyl 2-(((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-fluoromalonate

There total 3 articles about (R)-diethyl 2-(((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-fluoromalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 685-88-1
fluoromalonic acid diethyl ester

: 150884-50-7
benzaldehyde N-boc imine

: 1236292-94-6
(R)-diethyl 2-(((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-fluoromalonate

: 1236293-03-0
(S)-diethyl 2-(((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-fluoromalonate

Guidance literature:: fluoromalonic acid diethyl ester; With (S)-1-(1-(diphenylphosphino)-3-phenylpropan-2-yl)-3-(4-nitrophenyl)thiourea; acrylic acid methyl ester; In dichloromethane; at 20 ℃; for 0.166667h;

benzaldehyde N-boc imine; In diethyl ether; at 20 ℃; for 3h;
DOI:10.1002/anie.201409342

Reference yield: 86.0%

: 685-88-1
fluoromalonic acid diethyl ester

: 150884-50-7
benzaldehyde N-boc imine

: 1236292-94-6
(R)-diethyl 2-(((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-fluoromalonate

Guidance literature:: fluoromalonic acid diethyl ester; With 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea; In toluene; at 20 ℃; for 0.0833333h;

benzaldehyde N-boc imine; In toluene; at -78 ℃; for 91.2h; optical yield given as %ee; enantioselective reaction;
DOI:10.1055/s-0029-1218736