(N-4'-carboxybenzenesulfonyl)-3,4-dimethoxyphenylglycine

Base Information

• Chemical Name: (N-4'-carboxybenzenesulfonyl)-3,4-dimethoxyphenylglycine
• CAS No.: 235101-99-2
• Molecular Formula: C₁₇H₁₇NO₈S
• Molecular Weight: 395.39
• Mol file: 235101-99-2.mol

Synonyms:(N-4'-carboxybenzenesulfonyl)-3,4-dimethoxyphenylglycine

Chemical Property of (N-4'-carboxybenzenesulfonyl)-3,4-dimethoxyphenylglycine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (N-4'-carboxybenzenesulfonyl)-3,4-dimethoxyphenylglycine

There total 3 articles about (N-4'-carboxybenzenesulfonyl)-3,4-dimethoxyphenylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

p-carboxyphenylsulfonyl chloride (10130-89-9) + 3,4-dimethoxyphenylglycine hydrochloride (99076-40-1) → (N-4'-carboxybenzenesulfonyl)-3,4-dimethoxyphenylglycine (235101-99-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran;

DOI:10.1021/ol990526s

Reference yield:

1'-cyano-3,4-dimethoxybenzylamine (94782-89-5) → (N-4'-carboxybenzenesulfonyl)-3,4-dimethoxyphenylglycine (235101-99-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.56 g / aq. HCl / 2.5 h / Heating

2: 61 percent / aq. NaOH / tetrahydrofuran

With hydrogenchloride; sodium hydroxide; In tetrahydrofuran;

DOI:10.1021/ol990526s

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → (N-4'-carboxybenzenesulfonyl)-3,4-dimethoxyphenylglycine (235101-99-2)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium chloride; aq. NH₃ / methanol

2: 0.56 g / aq. HCl / 2.5 h / Heating

3: 61 percent / aq. NaOH / tetrahydrofuran

With hydrogenchloride; ammonium hydroxide; sodium hydroxide; ammonium chloride; In tetrahydrofuran; methanol;

DOI:10.1021/ol990526s

upstream raw materials:

p-carboxyphenylsulfonyl chloride

3,4-dimethoxyphenylglycine hydrochloride

1'-cyano-3,4-dimethoxybenzylamine

3,4-dimethoxy-benzaldehyde

Downstream raw materials:

C₂₄H₁₉F₅N₂O₇S