azetidine-1,2-dicarboxylic acid-1-[(4-chloro-phenyl)-amide]-2-[(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide] trifluoroacetate

Base Information

Chemical Name:azetidine-1,2-dicarboxylic acid-1-[(4-chloro-phenyl)-amide]-2-[(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide] trifluoroacetate
CAS No.:1080645-27-7
Molecular Formula:C₂HF₃O₂*C₂₁H₂₃ClN₄O₂
Molecular Weight:512.916
Hs Code.:

Synonyms:azetidine-1,2-dicarboxylic acid-1-[(4-chloro-phenyl)-amide]-2-[(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide] trifluoroacetate

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Chemical Property of azetidine-1,2-dicarboxylic acid-1-[(4-chloro-phenyl)-amide]-2-[(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide] trifluoroacetate

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Technology Process of azetidine-1,2-dicarboxylic acid-1-[(4-chloro-phenyl)-amide]-2-[(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide] trifluoroacetate

There total 2 articles about azetidine-1,2-dicarboxylic acid-1-[(4-chloro-phenyl)-amide]-2-[(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide] trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1080645-71-1
tert.butyl 2-(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-ylcarbamoyl)-azetidine-1-carboxylate trifluoroacetate

: 104-12-1
p-chlorphenylisocyanate

: 76-05-1
trifluoroacetic acid

: 1080645-27-7
azetidine-1,2-dicarboxylic acid-1-[(4-chloro-phenyl)-amide]-2-[(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide] trifluoroacetate

Guidance literature:: tert.butyl 2-(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-ylcarbamoyl)-azetidine-1-carboxylate trifluoroacetate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

p-chlorphenylisocyanate; With 4-methyl-morpholine; In dichloromethane; for 1.5h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 14097-37-1
2-methyl-1,2,3,4-tetrahydroisoquinolin-6-amine

: 1080645-27-7
azetidine-1,2-dicarboxylic acid-1-[(4-chloro-phenyl)-amide]-2-[(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide] trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 1 h / 20 °C

1.2: 1 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

2.2: 1.5 h

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;