isopropyl (R)-2-hydroxy-2-((S)-2-oxocyclohexyl)-4-phenylbut-(E)-3-enoate

Base Information

• Chemical Name: isopropyl (R)-2-hydroxy-2-((S)-2-oxocyclohexyl)-4-phenylbut-(E)-3-enoate
• CAS No.: 1129491-16-2
• Molecular Formula: C₁₉H₂₄O₄
• Molecular Weight: 316.397
• Mol file: 1129491-16-2.mol

Synonyms:isopropyl (R)-2-hydroxy-2-((S)-2-oxocyclohexyl)-4-phenylbut-(E)-3-enoate

Chemical Property of isopropyl (R)-2-hydroxy-2-((S)-2-oxocyclohexyl)-4-phenylbut-(E)-3-enoate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of isopropyl (R)-2-hydroxy-2-((S)-2-oxocyclohexyl)-4-phenylbut-(E)-3-enoate

There total 2 articles about isopropyl (R)-2-hydroxy-2-((S)-2-oxocyclohexyl)-4-phenylbut-(E)-3-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + isopropyl (E)-2-oxo-4-phenylbut-3-enoate → isopropyl (R)-2-hydroxy-2-((S)-2-oxocyclohexyl)-4-phenylbut-(E)-3-enoate (1129491-16-2)

Guidance literature:

With (2S,4R)-4-((tert-butyldiphenylsilyl)oxy)pyrrolidine-2-carboxylic acid; In water; at 20 ℃; for 18h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/adsc.200800248

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + isopropyl (E)-2-oxo-4-phenylbut-3-enoate → isopropyl (R)-2-hydroxy-2-((S)-2-oxocyclohexyl)-4-phenylbut-(E)-3-enoate (1129491-16-2) + C19H24O4

Guidance literature:

cyclohexanone; With 4-nitro-phenol; C₂₄H₃₉N₃S; In dichloromethane; at 20 ℃; for 0.166667h;

isopropyl (E)-2-oxo-4-phenylbut-3-enoate; In dichloromethane; for 72h; Overall yield = 58 %; stereoselective reaction;

DOI:10.1002/cjoc.201400431

upstream raw materials:

cyclohexanone