(+/-)-methyl 1-{[N-benzyl-2-FMOC-aminobutyrimidoyl]amino}-3-chloro-1H-pyrrolo-2-carboxylate

Base Information

• Chemical Name: (+/-)-methyl 1-{[N-benzyl-2-FMOC-aminobutyrimidoyl]amino}-3-chloro-1H-pyrrolo-2-carboxylate
• CAS No.: 628734-05-4
• Molecular Formula: C₃₂H₃₁ClN₄O₄
• Molecular Weight: 571.076
• Mol file: 628734-05-4.mol

Synonyms:(+/-)-methyl 1-{[N-benzyl-2-FMOC-aminobutyrimidoyl]amino}-3-chloro-1H-pyrrolo-2-carboxylate

Chemical Property of (+/-)-methyl 1-{[N-benzyl-2-FMOC-aminobutyrimidoyl]amino}-3-chloro-1H-pyrrolo-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (+/-)-methyl 1-{[N-benzyl-2-FMOC-aminobutyrimidoyl]amino}-3-chloro-1H-pyrrolo-2-carboxylate

There total 1 articles about (+/-)-methyl 1-{[N-benzyl-2-FMOC-aminobutyrimidoyl]amino}-3-chloro-1H-pyrrolo-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

(+/-)-N'-benzyl-N-FMOC-2-aminobutyrylthioamide (628733-85-7) + methyl 1-amino-5-chloro-1H-pyrrole-2-carboxylate, hydrochloride salt (628734-04-3) → (+/-)-methyl 1-{[N-benzyl-2-FMOC-aminobutyrimidoyl]amino}-3-chloro-1H-pyrrolo-2-carboxylate (628734-05-4)

Guidance literature:

(+/-)-N'-benzyl-N-FMOC-2-aminobutyrylthioamide; methyl 1-amino-5-chloro-1H-pyrrole-2-carboxylate, hydrochloride salt; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 48h;

Reference yield: 68.0%

(+/-)-methyl 1-{[N-benzyl-2-FMOC-aminobutyrimidoyl]amino}-3-chloro-1H-pyrrolo-2-carboxylate (628734-05-4) → (+/-)-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-carbamic acid 9H-fluoren-9-yl methyl ester (628734-06-5)

Guidance literature:

In xylene; at 149 ℃; for 168h;

upstream raw materials:

(+/-)-N'-benzyl-N-FMOC-2-aminobutyrylthioamide

methyl 1-amino-5-chloro-1H-pyrrole-2-carboxylate, hydrochloride salt

Downstream raw materials:

(+/-)-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-carbamic acid 9H-fluoren-9-yl methyl ester