N⁽⁶⁾-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylidene-8-{[(4-methoxyphenyl)diphenylmethoxy]methyl}adenosine

Base Information

• Chemical Name: N⁽⁶⁾-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylidene-8-{[(4-methoxyphenyl)diphenylmethoxy]methyl}adenosine
• CAS No.: 1040239-11-9
• Molecular Formula: C₄₉H₅₇N₅O₇Si
• Molecular Weight: 856.106

Synonyms:N⁽⁶⁾-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylidene-8-{[(4-methoxyphenyl)diphenylmethoxy]methyl}adenosine

Chemical Property of N⁽⁶⁾-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylidene-8-{[(4-methoxyphenyl)diphenylmethoxy]methyl}adenosine

Chemical Property:

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Technology Process of N⁽⁶⁾-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylidene-8-{[(4-methoxyphenyl)diphenylmethoxy]methyl}adenosine

There total 1 articles about N⁽⁶⁾-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylidene-8-{[(4-methoxyphenyl)diphenylmethoxy]methyl}adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(4-methoxyphenyl)diphenylmethyl chloride + N(6)-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-8-(hydroxymethyl)-2',3'-O-isopropylideneadenosine (801316-89-2) → N(6)-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylidene-8-{[(4-methoxyphenyl)diphenylmethoxy]methyl}adenosine (1040239-11-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 23 ℃; for 4.16667h; Inert atmosphere;

DOI:10.1002/hlca.200890071

Reference yield: 94.0%

N(6)-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylidene-8-{[(4-methoxyphenyl)diphenylmethoxy]methyl}adenosine (1040239-11-9) → 5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylidene-8-{[(4-methoxyphenyl)(diphenyl)methoxy]methyl}adenosine (1107653-06-4)

Guidance literature:

With sodium methylate; In methanol; at 0 - 25 ℃;

DOI:10.1002/hlca.200890236

Reference yield: 82.0%

N(6)-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylidene-8-{[(4-methoxyphenyl)diphenylmethoxy]methyl}adenosine (1040239-11-9) → N(6)-benzoyl-2',3'-O-isopropylidene-8-{[(4-methoxyphenyl)diphenylmethoxy]methyl}adenosine (1040239-15-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 23 ℃; for 4.25h; Molecular sieve;

DOI:10.1002/hlca.200890071

upstream raw materials:

N⁽⁶⁾-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-8-(hydroxymethyl)-2',3'-O-isopropylideneadenosine

Downstream raw materials:

N⁽⁶⁾-benzoyl-2',3'-O-isopropylidene-8-{[(4-methoxyphenyl)diphenylmethoxy]methyl}adenosine

5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylidene-8-{[(4-methoxyphenyl)(diphenyl)methoxy]methyl}adenosine

N₆-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylidene-8-{[(4-methoxyphenyl)diphenylmethoxy]methyl}-1-methyladenosine

N₆-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylidene-8-{[(4-methoxyphenyl)diphenylmethoxy]methyl}-N₆-methyladenosine

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