2S,3R-N-(2,6-diphthalimido-3-(4-methoxyphenyl)hexanoyl)-8-aminoquinoline

Base Information

Chemical Name:2S,3R-N-(2,6-diphthalimido-3-(4-methoxyphenyl)hexanoyl)-8-aminoquinoline
CAS No.:1380433-21-5
Molecular Formula:C₃₈H₃₀N₄O₆
Molecular Weight:638.679
Hs Code.:

Synonyms:2S,3R-N-(2,6-diphthalimido-3-(4-methoxyphenyl)hexanoyl)-8-aminoquinoline

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Chemical Property of 2S,3R-N-(2,6-diphthalimido-3-(4-methoxyphenyl)hexanoyl)-8-aminoquinoline

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Technology Process of 2S,3R-N-(2,6-diphthalimido-3-(4-methoxyphenyl)hexanoyl)-8-aminoquinoline

There total 5 articles about 2S,3R-N-(2,6-diphthalimido-3-(4-methoxyphenyl)hexanoyl)-8-aminoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 696-62-8
para-iodoanisole

: 1380433-28-2
(S)-2,6-bis(1,3-dioxoisoindolin-2-yl)-N-(quinolin-8-yl)hexanamide

: 1380433-21-5
2S,3R-N-(2,6-diphthalimido-3-(4-methoxyphenyl)hexanoyl)-8-aminoquinoline

: 2S,3S-N-(2,6-diphthalimido-3-(4-methoxyphenyl)hexanoyl)-8-aminoquinoline

Guidance literature:: With silver(I) acetate; palladium diacetate; In toluene; at 60 ℃; for 77h; optical yield given as %de;
DOI:10.1002/anie.201200731

Reference yield:

: 70548-28-6
(S)-2,6-diphthalimidohexanyl chloride

: 1380433-21-5
2S,3R-N-(2,6-diphthalimido-3-(4-methoxyphenyl)hexanoyl)-8-aminoquinoline

: 2S,3S-N-(2,6-diphthalimido-3-(4-methoxyphenyl)hexanoyl)-8-aminoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 2,6-dimethylpyridine / dichloromethane / 20 °C

2: silver(I) acetate; palladium diacetate / toluene / 77 h / 60 °C

With 2,6-dimethylpyridine; silver(I) acetate; palladium diacetate; In dichloromethane; toluene;
DOI:10.1002/anie.201200731

Reference yield:

: 29679-02-5,6298-08-4
(S)-2,6-bis(1,3-dioxoisoindolin-2-yl)hexanoic acid

: 1380433-21-5
2S,3R-N-(2,6-diphthalimido-3-(4-methoxyphenyl)hexanoyl)-8-aminoquinoline

: 2S,3S-N-(2,6-diphthalimido-3-(4-methoxyphenyl)hexanoyl)-8-aminoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / toluene / 2 h / 80 °C

2: 2,6-dimethylpyridine / dichloromethane / 20 °C

3: silver(I) acetate; palladium diacetate / toluene / 77 h / 60 °C

With 2,6-dimethylpyridine; silver(I) acetate; palladium diacetate; N,N-dimethyl-formamide; In dichloromethane; toluene;
DOI:10.1002/anie.201200731