hexahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester 3-methyl ester

Base Information

Chemical Name:hexahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester 3-methyl ester
CAS No.:1257235-74-7
Molecular Formula:C₂₁H₂₈N₂O₆
Molecular Weight:404.463
Hs Code.:

Synonyms:hexahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester 3-methyl ester

Suppliers and Price of hexahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester 3-methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of hexahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester 3-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of hexahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester 3-methyl ester

There total 21 articles about hexahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester 3-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 1257235-66-7
hexahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester

: 1257235-74-7
hexahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester 3-methyl ester

Guidance literature:: In diethyl ether; ethyl acetate;

Reference yield:

: 187039-57-2,335280-19-8
(2S,3S)-1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid

: 1257235-74-7
hexahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester 3-methyl ester

Guidance literature:: Multi-step reaction with 14 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 90 °C

2.1: 1H-imidazole / dichloromethane / 6 h / 0 - 20 °C

3.1: lithium borohydride / tetrahydrofuran / 3 h / 0 - 20 °C

4.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 20 °C

5.1: triethylamine / 12 h

6.1: thionyl chloride / dichloromethane / 1 h / -78 °C

6.2: 1 h / -78 °C

7.1: / acetonitrile / 16 h / 20 °C

8.1: hydrogen / ethanol / 1.5 h / 2585.81 Torr

9.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 - 45 °C

11.1: dmap / dichloromethane / 3 h / 0 °C

12.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

13.1: sodium periodate / ruthenium(III) trichloride hydrate / 1-methyl-pyrrolidin-2-one; tetrachloromethane; acetonitrile; water / 3.83 h

14.1: ethyl acetate; diethyl ether

With 1H-imidazole; dmap; sodium periodate; lithium borohydride; thionyl chloride; tetrabutyl ammonium fluoride; hydrogen; sulfur trioxide pyridine complex; sodium hydride; potassium carbonate; triethylamine; ruthenium(III) trichloride hydrate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1257235-74-7
hexahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester 3-methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 - 45 °C

3: dmap / dichloromethane / 3 h / 0 °C

4: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

5: sodium periodate / ruthenium(III) trichloride hydrate / 1-methyl-pyrrolidin-2-one; tetrachloromethane; acetonitrile; water / 3.83 h

6: ethyl acetate; diethyl ether

With dmap; sodium periodate; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; ruthenium(III) trichloride hydrate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; tetrachloromethane; diethyl ether; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;