(1'R,3'R)-2-(benzyloxycarbonylamino)-3-(3'-acetyl-2',2'-dimethylcyclobutyl)-(Z)-2-propenoic acid

Base Information

Chemical Name:(1'R,3'R)-2-(benzyloxycarbonylamino)-3-(3'-acetyl-2',2'-dimethylcyclobutyl)-(Z)-2-propenoic acid
CAS No.:608536-60-3
Molecular Formula:C₁₉H₂₃NO₅
Molecular Weight:345.395
Hs Code.:

Synonyms:(1'R,3'R)-2-(benzyloxycarbonylamino)-3-(3'-acetyl-2',2'-dimethylcyclobutyl)-(Z)-2-propenoic acid

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Chemical Property of (1'R,3'R)-2-(benzyloxycarbonylamino)-3-(3'-acetyl-2',2'-dimethylcyclobutyl)-(Z)-2-propenoic acid

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Technology Process of (1'R,3'R)-2-(benzyloxycarbonylamino)-3-(3'-acetyl-2',2'-dimethylcyclobutyl)-(Z)-2-propenoic acid

There total 1 articles about (1'R,3'R)-2-(benzyloxycarbonylamino)-3-(3'-acetyl-2',2'-dimethylcyclobutyl)-(Z)-2-propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 288848-45-3
methyl (1'R,3'R)-2-benzyloxycarbonylamino-3-[2',2'-dimethyl-3'-(2-methyl-1,3-dioxolan-2-yl)cyclobutyl]-(Z)-2-propenoate

: 608536-60-3
(1'R,3'R)-2-(benzyloxycarbonylamino)-3-(3'-acetyl-2',2'-dimethylcyclobutyl)-(Z)-2-propenoic acid

Guidance literature:: methyl (1'R,3'R)-2-benzyloxycarbonylamino-3-[2',2'-dimethyl-3'-(2-methyl-1,3-dioxolan-2-yl)cyclobutyl]-(Z)-2-propenoate; With potassium carbonate; In methanol; water; at 20 ℃; for 12h;

With hydrogenchloride; In water; at 20 ℃; for 12h; pH=2;
DOI:10.1016/S0957-4166(03)00485-3

Reference yield: 85.0%

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 608536-60-3
(1'R,3'R)-2-(benzyloxycarbonylamino)-3-(3'-acetyl-2',2'-dimethylcyclobutyl)-(Z)-2-propenoic acid

: 608536-62-5
(1'R,3'R)-2-(benzyloxycarbonylamino)-3-(3'-acetyl-2',2'-dimethylcyclobutyl)-(Z)-2-propenoic acid N-(methoxycarbonylmethyl)amide

Guidance literature:: With TEA; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 20h;
DOI:10.1016/S0957-4166(03)00485-3

Reference yield: 81.0%

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 608536-60-3
(1'R,3'R)-2-(benzyloxycarbonylamino)-3-(3'-acetyl-2',2'-dimethylcyclobutyl)-(Z)-2-propenoic acid

: 608536-64-7
(1'R,3'R)-2-(benzyloxycarbonylamino)-3-(3'-acetyl-2',2'-dimethylcyclobutyl)-(Z)-2-propenoic acid N-[(S)-(benzyl)(methoxycarbonyl)methyl]amide

Guidance literature:: With TEA; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 20h;
DOI:10.1016/S0957-4166(03)00485-3