(4E)-2,6-di(1H-pyrazol-1-yl)-4-styrylpyridine

Base Information

Chemical Name:(4E)-2,6-di(1H-pyrazol-1-yl)-4-styrylpyridine
CAS No.:1313048-84-8
Molecular Formula:C₁₉H₁₅N₅
Molecular Weight:313.362
Hs Code.:

Synonyms:(4E)-2,6-di(1H-pyrazol-1-yl)-4-styrylpyridine

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Chemical Property of (4E)-2,6-di(1H-pyrazol-1-yl)-4-styrylpyridine

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Technology Process of (4E)-2,6-di(1H-pyrazol-1-yl)-4-styrylpyridine

There total 3 articles about (4E)-2,6-di(1H-pyrazol-1-yl)-4-styrylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 2,6-di(1H-pyrazol-1-yl)isonicotinaldehyde

: 884-90-2
benzyl diethyl phosphate

: 1313048-83-7
(4Z)-2,6-di(1H-pyrazol-1-yl)-4-styrylpyridine

: 1313048-84-8
(4E)-2,6-di(1H-pyrazol-1-yl)-4-styrylpyridine

Guidance literature:: benzyl diethyl phosphate; With n-butyllithium; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 1h; Inert atmosphere;

2,6-di(1H-pyrazol-1-yl)isonicotinaldehyde; In tetrahydrofuran; hexane; at 20 ℃; for 3h; optical yield given as %de; Inert atmosphere;
DOI:10.1039/c1cc11850a

Reference yield: 49.0%

: 2,6-di(1H-pyrazol-1-yl)isonicotinaldehyde

: 128399-10-0
benzyltris(2-(methoxymethoxy)phenyl)phosphonium bromide

: 1313048-83-7
(4Z)-2,6-di(1H-pyrazol-1-yl)-4-styrylpyridine

: 1313048-84-8
(4E)-2,6-di(1H-pyrazol-1-yl)-4-styrylpyridine

Guidance literature:: benzyltris(2-(methoxymethoxy)phenyl)phosphonium bromide; With n-butyllithium; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 1h; Inert atmosphere;

2,6-di(1H-pyrazol-1-yl)isonicotinaldehyde; In tetrahydrofuran; hexane; at -78 - -40 ℃; for 18h; optical yield given as %de; Inert atmosphere;
DOI:10.1039/c1cc11850a

Reference yield:

: 924633-24-9
2,6-di-(pyrazol-1-yl)-4-(hydroxymethyl)pyridine

: 1313048-83-7
(4Z)-2,6-di(1H-pyrazol-1-yl)-4-styrylpyridine

: 1313048-84-8
(4E)-2,6-di(1H-pyrazol-1-yl)-4-styrylpyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: manganese(IV) oxide / dichloromethane / 24 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 18 h / -78 - -40 °C / Inert atmosphere

With manganese(IV) oxide; n-butyllithium; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1039/c1cc11850a