diisopropyl-phosphoramidous acid 2-cyano-ethyl ester 4-[2-(4-methoxy-phenyl)-[1,3]dioxolan-4-yl]-butyl ester

Base Information

• Chemical Name: diisopropyl-phosphoramidous acid 2-cyano-ethyl ester 4-[2-(4-methoxy-phenyl)-[1,3]dioxolan-4-yl]-butyl ester
• CAS No.: 388633-50-9
• Molecular Formula: C₂₃H₃₇N₂O₅P
• Molecular Weight: 452.531

Synonyms:diisopropyl-phosphoramidous acid 2-cyano-ethyl ester 4-[2-(4-methoxy-phenyl)-[1,3]dioxolan-4-yl]-butyl ester

Chemical Property of diisopropyl-phosphoramidous acid 2-cyano-ethyl ester 4-[2-(4-methoxy-phenyl)-[1,3]dioxolan-4-yl]-butyl ester

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Technology Process of diisopropyl-phosphoramidous acid 2-cyano-ethyl ester 4-[2-(4-methoxy-phenyl)-[1,3]dioxolan-4-yl]-butyl ester

There total 3 articles about diisopropyl-phosphoramidous acid 2-cyano-ethyl ester 4-[2-(4-methoxy-phenyl)-[1,3]dioxolan-4-yl]-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) + 4-[2-(4-Methoxyphenyl)-[1,3]-dioxolan-4-yl]butan-1-ol → diisopropyl-phosphoramidous acid 2-cyano-ethyl ester 4-[2-(4-methoxy-phenyl)-[1,3]dioxolan-4-yl]-butyl ester (388633-50-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1002/1521-3765(20010917)7:18<3976::AID-CHEM3976>3.0.CO;2-X

Reference yield:

hexane-1,2,6-triol (106-69-4,112254-74-7) → diisopropyl-phosphoramidous acid 2-cyano-ethyl ester 4-[2-(4-methoxy-phenyl)-[1,3]dioxolan-4-yl]-butyl ester (388633-50-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / pyridinium p-toluenesulfonate / dimethylformamide / 20 h / 50 °C

2: 82 percent / DIEA / CH₂Cl₂ / 2 h / 20 °C

With pyridinium p-toluenesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/1521-3765(20010917)7:18<3976::AID-CHEM3976>3.0.CO;2-X

Reference yield:

p-Anisaldehyde dimethyl acetal (2186-92-7) → diisopropyl-phosphoramidous acid 2-cyano-ethyl ester 4-[2-(4-methoxy-phenyl)-[1,3]dioxolan-4-yl]-butyl ester (388633-50-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / pyridinium p-toluenesulfonate / dimethylformamide / 20 h / 50 °C

2: 82 percent / DIEA / CH₂Cl₂ / 2 h / 20 °C

With pyridinium p-toluenesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/1521-3765(20010917)7:18<3976::AID-CHEM3976>3.0.CO;2-X

upstream raw materials:

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

hexane-1,2,6-triol

p-Anisaldehyde dimethyl acetal

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