N-((1-(2-(2-(4-methoxy-N,2,6-trimethylphenylsulfonamido)ethoxy)acetyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

Base Information

Chemical Name:N-((1-(2-(2-(4-methoxy-N,2,6-trimethylphenylsulfonamido)ethoxy)acetyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide
CAS No.:1186240-25-4
Molecular Formula:C₃₁H₄₆N₆O₆S
Molecular Weight:630.809
Hs Code.:

Synonyms:N-((1-(2-(2-(4-methoxy-N,2,6-trimethylphenylsulfonamido)ethoxy)acetyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

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Chemical Property of N-((1-(2-(2-(4-methoxy-N,2,6-trimethylphenylsulfonamido)ethoxy)acetyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

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Technology Process of N-((1-(2-(2-(4-methoxy-N,2,6-trimethylphenylsulfonamido)ethoxy)acetyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

There total 16 articles about N-((1-(2-(2-(4-methoxy-N,2,6-trimethylphenylsulfonamido)ethoxy)acetyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 766558-33-2
[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]acetic acid

: 1186241-53-1
C₁₇H₂₇N₅O

: 1186240-25-4
N-((1-(2-(2-(4-methoxy-N,2,6-trimethylphenylsulfonamido)ethoxy)acetyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; Inert atmosphere;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1186240-25-4
N-((1-(2-(2-(4-methoxy-N,2,6-trimethylphenylsulfonamido)ethoxy)acetyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / methanol; water / 0.5 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: lithium aluminium tetrahydride / diethyl ether / 0 °C

3.1: triethylamine / dichloromethane / 2 h / 25 °C

4.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

5.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; 1-hydroxy-7-aza-benzotriazole; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; water;

Reference yield:

: 766558-31-0
N-(2-hydroxyethyl)-4-methoxy-2,6,N-trimethylbenzenesulphonamide

: 1186240-25-4
N-((1-(2-(2-(4-methoxy-N,2,6-trimethylphenylsulfonamido)ethoxy)acetyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / tetrabutyl-ammonium chloride / water; toluene / 0 °C

2: hydrogenchloride / 1,4-dioxane / 20 °C

3: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; tetrabutyl-ammonium chloride; In 1,4-dioxane; dichloromethane; water; toluene;