2-(4-{[(E)-6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-ylimino]-methyl}-phenoxy)-N-(4-hydroxy-phenyl)-acetamide

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Chemical Name:2-(4-{[(E)-6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-ylimino]-methyl}-phenoxy)-N-(4-hydroxy-phenyl)-acetamide
CAS No.:96865-96-2
Molecular Formula:C₂₅H₂₉N₅O₅
Molecular Weight:479.536
Hs Code.:

Synonyms:2-(4-{[(E)-6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-ylimino]-methyl}-phenoxy)-N-(4-hydroxy-phenyl)-acetamide

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Chemical Property of 2-(4-{[(E)-6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-ylimino]-methyl}-phenoxy)-N-(4-hydroxy-phenyl)-acetamide

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Technology Process of 2-(4-{[(E)-6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-ylimino]-methyl}-phenoxy)-N-(4-hydroxy-phenyl)-acetamide

There total 3 articles about 2-(4-{[(E)-6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-ylimino]-methyl}-phenoxy)-N-(4-hydroxy-phenyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 81250-34-2
1,3-dipropyl-5,6-diaminouracil

: 96865-80-4
4-<<(4-hydoxyanilino)carbonyl>methoxy>benzaldehyde

: 96865-96-2
2-(4-{[(E)-6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-ylimino]-methyl}-phenoxy)-N-(4-hydroxy-phenyl)-acetamide

Guidance literature:: With acetic acid; In methanol; for 0.25h; Heating;
DOI:10.1021/jm00147a038

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 96865-96-2
2-(4-{[(E)-6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-ylimino]-methyl}-phenoxy)-N-(4-hydroxy-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / potassium carbonate / dimethylformamide / 72 h / 60 °C

2: 89 percent / dicyclohexylcarbodiimide, TEA / tetrahydrofuran; dimethylformamide / 2 h

3: 90 percent / acetic acid / methanol / 0.25 h / Heating

With TEA; potassium carbonate; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00147a038

Reference yield:

: 22042-71-3
(4-formylphenoxy)acetic acid

: 96865-96-2
2-(4-{[(E)-6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-ylimino]-methyl}-phenoxy)-N-(4-hydroxy-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / dicyclohexylcarbodiimide, TEA / tetrahydrofuran; dimethylformamide / 2 h

2: 90 percent / acetic acid / methanol / 0.25 h / Heating

With TEA; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00147a038