5,6-dihydroxy-2-(1-methyl-1-methylamino-ethyl)-pyrimidine-4-carboxylic acid 4-fluoro-benzylamide

Base Information

• Chemical Name: 5,6-dihydroxy-2-(1-methyl-1-methylamino-ethyl)-pyrimidine-4-carboxylic acid 4-fluoro-benzylamide
• CAS No.: 519028-28-5
• Molecular Formula: C₁₆H₁₉FN₄O₃
• Molecular Weight: 334.35

Synonyms:5,6-dihydroxy-2-(1-methyl-1-methylamino-ethyl)-pyrimidine-4-carboxylic acid 4-fluoro-benzylamide

Chemical Property of 5,6-dihydroxy-2-(1-methyl-1-methylamino-ethyl)-pyrimidine-4-carboxylic acid 4-fluoro-benzylamide

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Technology Process of 5,6-dihydroxy-2-(1-methyl-1-methylamino-ethyl)-pyrimidine-4-carboxylic acid 4-fluoro-benzylamide

There total 5 articles about 5,6-dihydroxy-2-(1-methyl-1-methylamino-ethyl)-pyrimidine-4-carboxylic acid 4-fluoro-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-{1-[benzyl(methyl)amino]-1-methylethyl}-N-(4-fluorobenzyl)-5,6-dihydroxypyrimidine-4-carboxamide (519032-37-2) → 5,6-dihydroxy-2-(1-methyl-1-methylamino-ethyl)-pyrimidine-4-carboxylic acid 4-fluoro-benzylamide (519028-28-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 2h;

DOI:10.1021/jm070027u

Reference yield:

2-(1-amino-1-methylethyl)-N-(4-fluorobenzyl)-5,6-dihydroxypyrimidine-4-carboxamide (519028-41-2) → 5,6-dihydroxy-2-(1-methyl-1-methylamino-ethyl)-pyrimidine-4-carboxylic acid 4-fluoro-benzylamide (519028-28-5)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N; NaBH₃CN; AcOH / methanol / 4 h / 20 °C

2: Et₃N; NaBH₃CN; AcOH / H₂O; methanol / 20 °C

3: H₂ / Pd/C / methanol / 2 h

With hydrogen; sodium cyanoborohydride; acetic acid; triethylamine; palladium on activated charcoal; In methanol; water;

DOI:10.1021/jm070027u

Reference yield:

methyl 2-(1-{[(benzyloxy) carbonyl] amino}-1-methylethyl)-5,6-dihydroxypyrimidine-4-carboxylate (519032-08-7) → 5,6-dihydroxy-2-(1-methyl-1-methylamino-ethyl)-pyrimidine-4-carboxylic acid 4-fluoro-benzylamide (519028-28-5)

Guidance literature:

Multi-step reaction with 5 steps

1: methanol / Heating

2: H₂ / Pd/C / methanol / 1 h / 20 °C

3: Et₃N; NaBH₃CN; AcOH / methanol / 4 h / 20 °C

4: Et₃N; NaBH₃CN; AcOH / H₂O; methanol / 20 °C

5: H₂ / Pd/C / methanol / 2 h

With hydrogen; sodium cyanoborohydride; acetic acid; triethylamine; palladium on activated charcoal; In methanol; water;

DOI:10.1021/jm070027u

upstream raw materials:

2-{1-[benzyl(methyl)amino]-1-methylethyl}-N-(4-fluorobenzyl)-5,6-dihydroxypyrimidine-4-carboxamide

2-(1-amino-1-methylethyl)-N-(4-fluorobenzyl)-5,6-dihydroxypyrimidine-4-carboxamide

methyl 2-(1-{[(benzyloxy) carbonyl] amino}-1-methylethyl)-5,6-dihydroxypyrimidine-4-carboxylate

2-(1-benzylamino-1-methyl-ethyl)-5,6-dihydroxy-pyrimidine-4-carboxylic acid 4-fluoro-benzylamide

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