1,3-benzodioxol-5-yl 2-chlorobenzoate

Base Information

• Chemical Name: 1,3-benzodioxol-5-yl 2-chlorobenzoate
• CAS No.: 16386-48-4
• Molecular Formula: C₁₄H₉ClO₄
• Molecular Weight: 276.676
• Mol file: 16386-48-4.mol

Synonyms:benzo[d][1,3]dioxol-5-yl 2-chlorobenzoate

Chemical Property of 1,3-benzodioxol-5-yl 2-chlorobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-benzodioxol-5-yl 2-chlorobenzoate

There total 3 articles about 1,3-benzodioxol-5-yl 2-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Sesamol (533-31-3) + o-chlorobenzoyl chloride (609-65-4) → benzo[d][1,3]dioxol-5-yl 2-chlorobenzoate (16386-48-4)

Guidance literature:

With pyridine; benzene;

DOI:10.1021/jf60059a002

Reference yield:

ortho-chlorobenzoic acid (118-91-2) → benzo[d][1,3]dioxol-5-yl 2-chlorobenzoate (16386-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Reflux

2: dichloromethane / 2 h / 25 °C

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1016/j.bioorg.2020.104381

Reference yield:

piperonal (120-57-0,30024-74-9) → benzo[d][1,3]dioxol-5-yl 2-chlorobenzoate (16386-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1: peroxyacetic acid; acetic acid; toluene-4-sulfonic acid / Erwaermen des Reaktionsgemisches mit aethanol. Kalilauge

2: benzene; pyridine

With pyridine; peracetic acid; toluene-4-sulfonic acid; acetic acid; benzene;

DOI:10.1021/jf60059a002

upstream raw materials:

Sesamol

o-chlorobenzoyl chloride

piperonal

ortho-chlorobenzoic acid

Refernces

• 1、 Zhou, Shiyang,Zou, Huiying,Huang, Gangliang,Chen, Guangying. "Preparations and antioxidant activities of sesamol and it's derivatives". . . Retrieved 2021.