(S)-2-Benzyl-N-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-thiazol-4-yl-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

Base Information

Chemical Name:(S)-2-Benzyl-N-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-thiazol-4-yl-ethyl]-4-morpholin-4-yl-4-oxo-butyramide
CAS No.:141115-19-7
Molecular Formula:C₃₅H₅₂N₄O₆S
Molecular Weight:656.887
Hs Code.:

Synonyms:(S)-2-Benzyl-N-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-thiazol-4-yl-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

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Chemical Property of (S)-2-Benzyl-N-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-thiazol-4-yl-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

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Technology Process of (S)-2-Benzyl-N-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-thiazol-4-yl-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

There total 8 articles about (S)-2-Benzyl-N-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-thiazol-4-yl-ethyl]-4-morpholin-4-yl-4-oxo-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 131288-25-0
Benzyl (2S)-2-Benzyl-3-t-butoxycarbonyl Propionate

: 141115-19-7
(S)-2-Benzyl-N-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-thiazol-4-yl-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

Guidance literature:: Multi-step reaction with 4 steps

1: CF₃CO₂H / CH₂Cl₂ / 66 h / Ambient temperature

2: 1.) N-methylmorpholine (NMM), isobutyl chloroformate / 1.) CH₂Cl₂, 0-20 deg C, 30 min, 2.) CH₂Cl₂, RT, overnight

3: 90 percent / H₂ / 10percent Pd/C / methanol / 1.5 h / 760 Torr

4: 1-hydroxybenzotriazole (HOBT), 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (EDC*HCl) / dimethylformamide / 24 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; isobutyl chloroformate; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00088a005

Reference yield:

: 140903-49-7
benzyl (2S)-2-benzyl-3-(4-morpholinylcarbonyl)propionate

: 141115-19-7
(S)-2-Benzyl-N-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-thiazol-4-yl-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / H₂ / 10percent Pd/C / methanol / 1.5 h / 760 Torr

2: 1-hydroxybenzotriazole (HOBT), 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (EDC*HCl) / dimethylformamide / 24 h / Ambient temperature

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00088a005

Reference yield:

: 140903-48-6
phenylmethyl 3-carboxy-2(S)-(phenylmethyl)-1-propanoate

: 141115-19-7
(S)-2-Benzyl-N-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-thiazol-4-yl-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) N-methylmorpholine (NMM), isobutyl chloroformate / 1.) CH₂Cl₂, 0-20 deg C, 30 min, 2.) CH₂Cl₂, RT, overnight

2: 90 percent / H₂ / 10percent Pd/C / methanol / 1.5 h / 760 Torr

3: 1-hydroxybenzotriazole (HOBT), 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (EDC*HCl) / dimethylformamide / 24 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; isobutyl chloroformate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00088a005