tetrahydrofuran-2-yl-[(S)-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl]-methanone

Base Information

• Chemical Name: tetrahydrofuran-2-yl-[(S)-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl]-methanone
• CAS No.: 1152061-22-7
• Molecular Formula: C₂₂H₂₅NO₃
• Molecular Weight: 351.445
• Mol file: 1152061-22-7.mol

Synonyms:tetrahydrofuran-2-yl-[(S)-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl]-methanone

Chemical Property of tetrahydrofuran-2-yl-[(S)-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl]-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tetrahydrofuran-2-yl-[(S)-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl]-methanone

There total 1 articles about tetrahydrofuran-2-yl-[(S)-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

tetrahydro-2-furancarboxylic acid (16874-33-2) + (S)-α,α-diphenyl-2-pyrrolidine-2-methanol → tetrahydrofuran-2-yl-[(S)-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl]-methanone (1152061-25-0) + tetrahydrofuran-2-yl-[(S)-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl]-methanone (1152061-22-7)

Guidance literature:

tetrahydro-2-furancarboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 0.75h;

(S)-α,α-diphenyl-2-pyrrolidine-2-methanol; In tetrahydrofuran; for 24h;

DOI:10.1055/s-0028-1087532

Reference yield: 86.0%

tetrahydrofuran-2-yl-[(S)-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl]-methanone (1152061-22-7) → (R)-tetrahydro-2-furoic acid (87392-05-0)

Guidance literature:

With hydrogenchloride; water; at 90 ℃; for 20h;

DOI:10.1055/s-0028-1087532

upstream raw materials:

tetrahydro-2-furancarboxylic acid

Downstream raw materials:

(R)-tetrahydro-2-furoic acid

Refernces