(3-{3-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]phenylazo}phenyl)acetic acid

Base Information

• Chemical Name: (3-{3-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]phenylazo}phenyl)acetic acid
• CAS No.: 847834-90-6
• Molecular Formula: C₃₀H₂₅N₃O₄
• Molecular Weight: 491.546
• Mol file: 847834-90-6.mol

Synonyms:(3-{3-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]phenylazo}phenyl)acetic acid

Chemical Property of (3-{3-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]phenylazo}phenyl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-{3-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]phenylazo}phenyl)acetic acid

There total 6 articles about (3-{3-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]phenylazo}phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(3-{3-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]phenylazo}phenyl)acetic acid tert-butyl ester (847834-89-3) → (3-{3-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]phenylazo}phenyl)acetic acid (847834-90-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 36h;

DOI:10.1021/ja0442567

Reference yield:

(3-nitrobenzyl)carbamic acid 9H-fluoren-9-ylmethyl ester (847834-88-2) → (3-{3-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]phenylazo}phenyl)acetic acid (847834-90-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / H₂ / PtO₂ / ethanol; dioxane / 2 h / 750.06 Torr

2: 57 percent / AcOH / 48 h / 20 °C

3: 97 percent / trifluoroacetic acid / CH₂Cl₂ / 36 h

With hydrogen; acetic acid; trifluoroacetic acid; platinum(IV) oxide; In 1,4-dioxane; ethanol; dichloromethane;

DOI:10.1021/ja0442567

Reference yield:

3-nitro-benzeneacetic acid (1877-73-2) → (3-{3-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]phenylazo}phenyl)acetic acid (847834-90-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 88 percent / tributylamine; 2-chloro-1-methylpyridinium iodide / toluene / Heating

2.1: Zn; aq. NH₄Cl / 2-methoxy-ethanol / 6 h / 20 °C

2.2: aq. FeCl₃ / ethanol; 2-methoxy-ethanol / -10 - 20 °C

3.1: 57 percent / AcOH / 48 h / 20 °C

4.1: 97 percent / trifluoroacetic acid / CH₂Cl₂ / 36 h

With tributyl-amine; 2-chloro-1-methyl-pyridinium iodide; ammonium chloride; acetic acid; trifluoroacetic acid; zinc; In dichloromethane; 2-methoxy-ethanol; toluene;

DOI:10.1021/ja0442567

upstream raw materials:

(3-{3-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]phenylazo}phenyl)acetic acid tert-butyl ester

3-nitro-benzeneacetic acid

3-nitrophenylacetic acid t-butyl ester

(3-nitrobenzyl)carbamic acid 9H-fluoren-9-ylmethyl ester