{5-Methoxy-2-[1-trimethylsilanyl-3-((1S,2S)-1,8,8-trimethyl-2-vinyl-6,10-dioxa-spiro[4.5]dec-1-yl)-propyl]-benzyl}-dimethyl-amine

Base Information

Chemical Name:{5-Methoxy-2-[1-trimethylsilanyl-3-((1S,2S)-1,8,8-trimethyl-2-vinyl-6,10-dioxa-spiro[4.5]dec-1-yl)-propyl]-benzyl}-dimethyl-amine
CAS No.:86284-19-7
Molecular Formula:C₂₉H₄₉NO₃Si
Molecular Weight:487.798
Hs Code.:

Synonyms:{5-Methoxy-2-[1-trimethylsilanyl-3-((1S,2S)-1,8,8-trimethyl-2-vinyl-6,10-dioxa-spiro[4.5]dec-1-yl)-propyl]-benzyl}-dimethyl-amine

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Chemical Property of {5-Methoxy-2-[1-trimethylsilanyl-3-((1S,2S)-1,8,8-trimethyl-2-vinyl-6,10-dioxa-spiro[4.5]dec-1-yl)-propyl]-benzyl}-dimethyl-amine

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Technology Process of {5-Methoxy-2-[1-trimethylsilanyl-3-((1S,2S)-1,8,8-trimethyl-2-vinyl-6,10-dioxa-spiro[4.5]dec-1-yl)-propyl]-benzyl}-dimethyl-amine

There total 15 articles about {5-Methoxy-2-[1-trimethylsilanyl-3-((1S,2S)-1,8,8-trimethyl-2-vinyl-6,10-dioxa-spiro[4.5]dec-1-yl)-propyl]-benzyl}-dimethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83781-94-6
(2-chloro-5-methoxybenzyl)dimethylamine

: 86284-19-7
{5-Methoxy-2-[1-trimethylsilanyl-3-((1S,2S)-1,8,8-trimethyl-2-vinyl-6,10-dioxa-spiro[4.5]dec-1-yl)-propyl]-benzyl}-dimethyl-amine

Guidance literature:: Multi-step reaction with 3 steps

1: Ni

2: n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / 2 h / -20 - -10 °C

3: at -75 deg C to room temperature

With n-butyllithium; nickel; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/ja00392a046

Reference yield:

: 83781-94-6
(2-chloro-5-methoxybenzyl)dimethylamine

: 86284-19-7
{5-Methoxy-2-[1-trimethylsilanyl-3-((1R,2R)-1,8,8-trimethyl-2-vinyl-6,10-dioxa-spiro[4.5]dec-1-yl)-propyl]-benzyl}-dimethyl-amine

Guidance literature:: Multi-step reaction with 2 steps

1: (Ph₃P)2NiCl₂ / benzene; diethyl ether / 1.) room temperature, 2 h, 2.) reflux, 15 h

2: 1.) n-BuLi / 1.) THF, HMPA, -10 deg C - -20 deg C , 2 h, 2.) -20 deg C -> room temperature, overnight

With bis(triphenylphosphine)nickel(II) chloride; n-butyllithium; In diethyl ether; benzene;
DOI:10.1021/ja00390a036

Reference yield:

: 83781-91-3
2-((1R,2R)-1,8,8-Trimethyl-2-vinyl-6,10-dioxa-spiro[4.5]dec-1-yl)-ethanol

: 86284-19-7
{5-Methoxy-2-[1-trimethylsilanyl-3-((1R,2R)-1,8,8-trimethyl-2-vinyl-6,10-dioxa-spiro[4.5]dec-1-yl)-propyl]-benzyl}-dimethyl-amine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 5 h / 0 °C

2: LiBr*H₂O / dimethylformamide / 48 h / Ambient temperature

3: 1.) n-BuLi / 1.) THF, HMPA, -10 deg C - -20 deg C , 2 h, 2.) -20 deg C -> room temperature, overnight

With pyridine; n-butyllithium; lithium bromide; In N,N-dimethyl-formamide;
DOI:10.1021/ja00390a036