Technology Process of meptazinol para-amino-meta-ethylbenzoic acid carbamate
There total 5 articles about meptazinol para-amino-meta-ethylbenzoic acid carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere
2.1: sodium hydroxide; water / 22 h / Reflux; Inert atmosphere
2.2: pH 4 - 5
3.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere
4.1: triethylamine / toluene; tetrahydrofuran / 0.76 h / -75 - -60 °C
4.2: 0.75 h / -75 - -70 °C
5.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 18 h / 0 - 15 °C / Inert atmosphere
With
water; hydrogen; potassium carbonate; triethylamine; sodium hydroxide;
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
4.1: Schotten-Baumann Reaction;
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
tetrahydrofuran;
at 0 - 15 ℃;
for 18h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere
2.1: triethylamine / toluene; tetrahydrofuran / 0.76 h / -75 - -60 °C
2.2: 0.75 h / -75 - -70 °C
3.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 18 h / 0 - 15 °C / Inert atmosphere
With
hydrogen; potassium carbonate; triethylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
2.1: Schotten-Baumann Reaction;
