(2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl decanoate

Base Information

Chemical Name:(2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl decanoate
CAS No.:1303598-13-1
Molecular Formula:C₂₁H₃₀Cl₂N₂O₆
Molecular Weight:477.385
Hs Code.:

Synonyms:(2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl decanoate

Suppliers and Price of (2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl decanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl decanoate

Chemical Property:

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Technology Process of (2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl decanoate

There total 3 articles about (2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl decanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 4704-31-8
vinyl caprate

: 56-75-7,85666-84-8
chloramphenicol

: 1303598-13-1
(2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl decanoate

Guidance literature:: With Novozym 435; In acetonitrile; at 20 ℃; for 3h; regioselective reaction; Inert atmosphere; Enzymatic reaction;
DOI:10.1016/j.tet.2011.02.070

Reference yield:

: 4704-31-8
vinyl caprate

: 56-75-7,85666-84-8
chloramphenicol

: 1303598-13-1
(2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl decanoate

: 1303598-17-5
(1R,2R)-3-(decanoyloxy)-2-[(dichloroacetyl)amino]-1-(4-nitrophenyl)propyl decanoate

Guidance literature:: With Candida antarctica lipase A preparation; In 1,4-dioxane; at 30 ℃; for 48h; Enzymatic reaction;
DOI:10.1016/j.tet.2011.02.070

Reference yield:

: 10318-17-9
(1R,2R)-3-(acetyloxy)-2-[(dichloroacetyl)amino]-1-(4-nitrophenyl)propyl acetate

: 1303598-13-1
(2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl decanoate

Guidance literature:: Multi-step reaction with 2 steps

1: Novozym 435 / acetonitrile / 24 h / 20 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

2: Novozym 435 / acetonitrile / 3 h / 20 °C / Inert atmosphere; Enzymatic reaction

With Novozym 435; In acetonitrile;
DOI:10.1016/j.tet.2011.02.070