4-Chloro-8-methoxyquinoline

Base Information

Chemical Name:4-Chloro-8-methoxyquinoline
CAS No.:16778-21-5
Molecular Formula:C10H8ClNO
Molecular Weight:193.633
Hs Code.:2933499090
European Community (EC) Number:632-643-3
DSSTox Substance ID:DTXSID60491470
Nikkaji Number:J1.856.572B
Wikidata:Q72453522
Mol file:16778-21-5.mol

Synonyms:4-Chloro-8-methoxyquinoline;16778-21-5;4-chloro-8-methoxy-quinoline;Quinoline, 4-chloro-8-methoxy-;MFCD00033679;SCHEMBL2178344;DTXSID60491470;LCYDNBWXXPOMQL-UHFFFAOYSA-N;AKOS002675910;AB01541;AC-7289;CS-W015761;4-Chloro-8-methoxyquinoline, AldrichCPR;CS-11102;SY005498;FT-0618150;EN300-67695;A18288;J-650032

Suppliers and Price of 4-Chloro-8-methoxyquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Chloro-8-methoxyquinoline
1g
$ 185.00

SynQuest Laboratories
4-Chloro-8-methoxyquinoline
5 g
$ 816.00

SynQuest Laboratories
4-Chloro-8-methoxyquinoline
1 g
$ 296.00

Sigma-Aldrich
4-Chloro-8-methoxyquinoline Aldrich
1g
$ 223.00

J&W Pharmlab
4-Chloro-8-methoxy-quinoline 97%
25g
$ 998.00

Crysdot
4-Chloro-8-methoxyquinoline 97%
1g
$ 160.00

Crysdot
4-Chloro-8-methoxyquinoline 97%
10g
$ 660.00

Crysdot
4-Chloro-8-methoxyquinoline 97%
5g
$ 385.00

Chemenu
4-Chloro-8-methoxy-quinoline 97%
5g
$ 355.00

Chemcia Scientific
4-Chloro-8-methoxy-quinoline 95%
1 G
$ 100.00

Total 36 raw suppliers

Chemical Property of 4-Chloro-8-methoxyquinoline

Chemical Property:

Vapor Pressure:0.00207mmHg at 25°C
Melting Point:79-80 °C
Refractive Index:1.621
Boiling Point:299.9 °C at 760 mmHg
PKA:1.86±0.30(Predicted)
Flash Point:135.2 °C
PSA：22.12000
Density:1.267 g/cm³
LogP:2.89680
Storage Temp.:-20?C Freezer
Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:193.0294416
Heavy Atom Count:13
Complexity:176

Purity/Quality:

99%, ^*data from raw suppliers

4-Chloro-8-methoxyquinoline ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-41
Safety Statements: 26-39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC2=C(C=CN=C21)Cl
Uses A potent selective CRTh2(DP2) antagonist, as potential treatments for asthma, allergic rhinitis and other inflammatory diseases. A potent selective CRTh2(DP2) antagonist, as potential treatments for asthma, allergic rhinitis and other inflammatory diseases

Technology Process of 4-Chloro-8-methoxyquinoline

There total 7 articles about 4-Chloro-8-methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 21269-34-1
4-hydroxy-8-methoxyquinoline

: 16778-21-5
4-chloro-8-methoxyquinoline

Guidance literature:: With trichlorophosphate; for 3h; Heating;
DOI:10.1007/BF00823423

Reference yield:

: 28027-18-1
4-hydroxy-8-methoxyquinoline-3-carboxylic acid

: 16778-21-5
4-chloro-8-methoxyquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: diphenyl ether / Erhitzen auf Siedetemperatur

2: phosphoryl chloride; phosphorus (V)-chloride

With diphenylether; phosphorus pentachloride; trichlorophosphate;
DOI:10.1021/ja01211a040

Reference yield:

: 27568-04-3
Ethyl 4-hydroxy-8-methoxyquinoline-3-carboxylate

: 16778-21-5
4-chloro-8-methoxyquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: aqueous NaOH

2: diphenyl ether / Erhitzen auf Siedetemperatur

3: phosphoryl chloride; phosphorus (V)-chloride

With sodium hydroxide; diphenylether; phosphorus pentachloride; trichlorophosphate;
DOI:10.1021/ja01211a040