2-[6-isocyano-2,2,10,10-tetramethyl-11-(tetrahydropyran-2-yloxy)-6-(toluene-4-sulfonyl)-undecyloxy]-tetrahydropyran

Base Information

• Chemical Name: 2-[6-isocyano-2,2,10,10-tetramethyl-11-(tetrahydropyran-2-yloxy)-6-(toluene-4-sulfonyl)-undecyloxy]-tetrahydropyran
• CAS No.: 413626-97-8
• Molecular Formula: C₃₃H₅₃NO₆S
• Molecular Weight: 591.853

Synonyms:2-[6-isocyano-2,2,10,10-tetramethyl-11-(tetrahydropyran-2-yloxy)-6-(toluene-4-sulfonyl)-undecyloxy]-tetrahydropyran

Chemical Property of 2-[6-isocyano-2,2,10,10-tetramethyl-11-(tetrahydropyran-2-yloxy)-6-(toluene-4-sulfonyl)-undecyloxy]-tetrahydropyran

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 2-[6-isocyano-2,2,10,10-tetramethyl-11-(tetrahydropyran-2-yloxy)-6-(toluene-4-sulfonyl)-undecyloxy]-tetrahydropyran

There total 5 articles about 2-[6-isocyano-2,2,10,10-tetramethyl-11-(tetrahydropyran-2-yloxy)-6-(toluene-4-sulfonyl)-undecyloxy]-tetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) + 5-Bromo-2,2-dimethyl-1-(tetrahydropyranyloxy)-pentane (112402-14-9) → 2-[6-isocyano-2,2,10,10-tetramethyl-11-(tetrahydropyran-2-yloxy)-6-(toluene-4-sulfonyl)-undecyloxy]-tetrahydropyran (413626-97-8)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 20h;

DOI:10.1021/jm040006p

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → 2-[6-isocyano-2,2,10,10-tetramethyl-11-(tetrahydropyran-2-yloxy)-6-(toluene-4-sulfonyl)-undecyloxy]-tetrahydropyran (413626-97-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pTsOH*H₂O / CH₂Cl₂ / 20 °C

2: NaH; NBu₄I / dimethylsulfoxide / 20 h / 20 °C

With tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jm040006p

Reference yield:

ethyl 2,2-dimethyl-5-bromopentanoate (77858-42-5) → 2-[6-isocyano-2,2,10,10-tetramethyl-11-(tetrahydropyran-2-yloxy)-6-(toluene-4-sulfonyl)-undecyloxy]-tetrahydropyran (413626-97-8)

Guidance literature:

Multi-step reaction with 3 steps

1: LiBH₄; MeOH / CH₂Cl₂ / Heating

2: pTsOH*H₂O / CH₂Cl₂ / 20 °C

3: NaH; NBu₄I / dimethylsulfoxide / 20 h / 20 °C

With methanol; lithium borohydride; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jm040006p

upstream raw materials:

[(p-methylphenyl)sulfonylmethyl]isonitrile

5-Bromo-2,2-dimethyl-1-(tetrahydropyranyloxy)-pentane

3,4-dihydro-2H-pyran

ethyl 2,2-dimethyl-5-bromopentanoate

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