(-)-(2S,3S,6S,17S)-2,3-bis(tosyloxymethyl)-6,17-bis(methoxymethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane

Base Information

Chemical Name:(-)-(2S,3S,6S,17S)-2,3-bis(tosyloxymethyl)-6,17-bis(methoxymethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane
CAS No.:104128-69-0
Molecular Formula:C₃₂H₄₈O₁₄S₂
Molecular Weight:720.857
Hs Code.:

Synonyms:(-)-(2S,3S,6S,17S)-2,3-bis(tosyloxymethyl)-6,17-bis(methoxymethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane

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Chemical Property of (-)-(2S,3S,6S,17S)-2,3-bis(tosyloxymethyl)-6,17-bis(methoxymethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane

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Technology Process of (-)-(2S,3S,6S,17S)-2,3-bis(tosyloxymethyl)-6,17-bis(methoxymethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane

There total 4 articles about (-)-(2S,3S,6S,17S)-2,3-bis(tosyloxymethyl)-6,17-bis(methoxymethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 104144-27-6
((2S,3S,6S,17S)-3-Hydroxymethyl-6,17-bis-methoxymethyl-1,4,7,10,13,16-hexaoxa-cyclooctadec-2-yl)-methanol

: 98-59-9
p-toluenesulfonyl chloride

: 104128-69-0
(-)-(2S,3S,6S,17S)-2,3-bis(tosyloxymethyl)-6,17-bis(methoxymethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane

Guidance literature:: With pyridine; at 0 ℃; for 20h;

Reference yield:

: 104144-21-0
(R)-2-(2-{2-[2-((R)-1-Hydroxymethyl-2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-3-methoxy-propan-1-ol

: 104128-69-0
(-)-(2S,3S,6S,17S)-2,3-bis(tosyloxymethyl)-6,17-bis(methoxymethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane

Guidance literature:: Multi-step reaction with 4 steps

1: 56 percent / pyridine / 18 h / 0 °C

2: 50 percent / 60 percent NaH in oil / dimethylformamide / 17 h / 50 °C

3: 3.81 g / cc. HCl, H₂ / 5 percent Pd-C / ethanol / Ambient temperature

4: 83 percent / pyridine / 20 h / 0 °C

With pyridine; hydrogenchloride; hydrogen; sodium hydride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 104144-24-3
(2S,3S,6S,17S)-2,3-Bis-benzyloxymethyl-6,17-bis-methoxymethyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane

: 104128-69-0
(-)-(2S,3S,6S,17S)-2,3-bis(tosyloxymethyl)-6,17-bis(methoxymethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane

Guidance literature:: Multi-step reaction with 2 steps

1: 3.81 g / cc. HCl, H₂ / 5 percent Pd-C / ethanol / Ambient temperature

2: 83 percent / pyridine / 20 h / 0 °C

With pyridine; hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol;