diphenylmethyl (4S,7S)-6-benzyl-1-oxo-5-oxa-2,6-diazaspiro<3.4>octane-7-carboxylate

Base Information

Chemical Name:diphenylmethyl (4S*,7S*)-6-benzyl-1-oxo-5-oxa-2,6-diazaspiro<3.4>octane-7-carboxylate
CAS No.:108634-93-1
Molecular Formula:C₂₆H₂₄N₂O₄
Molecular Weight:428.488
Hs Code.:

Synonyms:diphenylmethyl (4S*,7S*)-6-benzyl-1-oxo-5-oxa-2,6-diazaspiro<3.4>octane-7-carboxylate

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Chemical Property of diphenylmethyl (4S*,7S*)-6-benzyl-1-oxo-5-oxa-2,6-diazaspiro<3.4>octane-7-carboxylate

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Technology Process of diphenylmethyl (4S*,7S*)-6-benzyl-1-oxo-5-oxa-2,6-diazaspiro<3.4>octane-7-carboxylate

There total 8 articles about diphenylmethyl (4S*,7S*)-6-benzyl-1-oxo-5-oxa-2,6-diazaspiro<3.4>octane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 108634-92-0
diphenylmethyl (4S*,7S*)-6-benzyl-2-hydroxy-1-oxo-5-oxa-2,6-diazaspiro <3.4> octane-7-carboxylate

: 108634-93-1
diphenylmethyl (4S*,7S*)-6-benzyl-1-oxo-5-oxa-2,6-diazaspiro<3.4>octane-7-carboxylate

Guidance literature:: With toluene-4-sulfonic acid; In 1,2-dichloro-ethane; at 72 ℃; for 48h;
DOI:10.1016/0008-6215(87)84004-1

Reference yield:

: 622-30-0
N-benzyl hydroxylalmine

: 108634-93-1
diphenylmethyl (4S*,7S*)-6-benzyl-1-oxo-5-oxa-2,6-diazaspiro<3.4>octane-7-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / calcium chloride / CHCl₃ / 4 h / Ambient temperature

2: 37 percent / CHCl₃ / 50 °C

3: 75 percent / H₂ / Pd-C / methanol / 0.5 h / 760 Torr

4: 80 percent / sodium acetate, 15percent TiCl₃ / tetrahydrofuran; H₂O / 2 h / Ambient temperature

With titanium(III) chloride; hydrogen; sodium acetate; calcium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; water;
DOI:10.1016/S0040-4020(01)87377-4

Reference yield:

: 20578-60-3
glyoxylic acid benzhydryl ester

: 108634-93-1
diphenylmethyl (4S*,7S*)-6-benzyl-1-oxo-5-oxa-2,6-diazaspiro<3.4>octane-7-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / calcium chloride / CHCl₃ / 4 h / Ambient temperature

2: 37 percent / CHCl₃ / 50 °C

3: 75 percent / H₂ / Pd-C / methanol / 0.5 h / 760 Torr

4: 80 percent / sodium acetate, 15percent TiCl₃ / tetrahydrofuran; H₂O / 2 h / Ambient temperature

With titanium(III) chloride; hydrogen; sodium acetate; calcium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; water;
DOI:10.1016/S0040-4020(01)87377-4