2-cyano-3-{[4-(dimethylamino)phenyl]ethynyl}but-2-ene-dinitrile

Base Information

• Chemical Name: 2-cyano-3-{[4-(dimethylamino)phenyl]ethynyl}but-2-ene-dinitrile
• CAS No.: 480430-25-9
• Molecular Formula: C₁₅H₁₀N₄
• Molecular Weight: 246.271
• Mol file: 480430-25-9.mol

Synonyms:2-cyano-3-{[4-(dimethylamino)phenyl]ethynyl}but-2-ene-dinitrile

Chemical Property of 2-cyano-3-{[4-(dimethylamino)phenyl]ethynyl}but-2-ene-dinitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cyano-3-{[4-(dimethylamino)phenyl]ethynyl}but-2-ene-dinitrile

There total 4 articles about 2-cyano-3-{[4-(dimethylamino)phenyl]ethynyl}but-2-ene-dinitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

N,N-dimethyl-4-[2-(trimethylstannyl)ethynyl]aniline (71450-29-8) + ethenetetracarbonitrile (670-54-2) → 2-cyano-3-{[4-(dimethylamino)phenyl]ethynyl}but-2-ene-dinitrile (480430-25-9)

Guidance literature:

In acetonitrile; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2017.05.009

Reference yield: 62.0%

ethenetetracarbonitrile (670-54-2) + 4-ethynyl-N,N-dimethylaniline (17573-94-3,752235-18-0) → 2-cyano-3-{[4-(dimethylamino)phenyl]ethynyl}but-2-ene-dinitrile (480430-25-9)

Guidance literature:

4-ethynyl-N,N-dimethylaniline; With n-butyllithium; In tetrahydrofuran; hexane; at -30 ℃; for 0.5h;

With zinc(II) chloride; In tetrahydrofuran; hexane; at -30 - 20 ℃; for 1.5h;

ethenetetracarbonitrile; In tetrahydrofuran; hexane; at 20 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2017.05.009

Reference yield: 29.0%

dibromofumaronitrile (29262-20-2) + 4-ethynyl-N,N-dimethylaniline (17573-94-3,752235-18-0) → 2-cyano-3-{[4-(dimethylamino)phenyl]ethynyl}but-2-ene-dinitrile (480430-25-9)

Guidance literature:

4-ethynyl-N,N-dimethylaniline; With copper (I) acetate; In tetrahydrofuran; at 20 ℃; for 0.833333h;

dibromofumaronitrile; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1002/chem.200500082

upstream raw materials:

ethenetetracarbonitrile

4-ethynyl-N,N-dimethylaniline

dibromofumaronitrile

N,N-dimethyl-4-[2-(trimethylstannyl)ethynyl]aniline

Downstream raw materials:

3-(dicyanomethylidene)-4-[4-(dimethylamino)phenyl]-1,4-pentadiene-1,1,2,5,5-pentacarbonitrile