5,6-diethyl-2,3-dihydro-1H-inden-2-amine Hydrochloride

Base Information

• Chemical Name: 5,6-diethyl-2,3-dihydro-1H-inden-2-amine Hydrochloride
• CAS No.: 312753-53-0
• Molecular Formula: C13H19N^.HCl
• Molecular Weight: 225.762
• Hs Code.: 2921499090
• European Community (EC) Number: 691-331-5
• DSSTox Substance ID: DTXSID30437042
• Mol file: 312753-53-0.mol

Synonyms:5,6-diethyl-2,3-dihydro-1H-inden-2-amine Hydrochloride;312753-53-0;5,6-diethylindan-1-one;5,6-diethyl-2,3-dihydro-1H-inden-2-amine;hydrochloride;MFCD13185940;5,6-Diethyl-2,3-dihydro-1h-inden-2-amine, HCl;2-Amino-5,6-diethylindane Hydrochloride;SCHEMBL866127;2-AMINO-5,6-DIETHYL-2,3-DIHYDRO-1H-INDENE HCL;5,6-Diethyl-2,3-dihydro-1H-inden-2-aminehydrochloride;DTXSID30437042;ZOVIYWYFBOQKIA-UHFFFAOYSA-N;BCP04728;AKOS015924667;CS-W020205;SB18035;AC-24698;DS-17728;SY107784;5,6-Diethyl-indan-2-ylamine hydrochloride;FT-0686954;5,6-Diethyl-2,3-dihydro-1H-inden-2-amine HCl;A846477;J-516521

Chemical Property of 5,6-diethyl-2,3-dihydro-1H-inden-2-amine Hydrochloride

Chemical Property:

• Vapor Pressure: 0.00285mmHg at 25°C
• Melting Point: >250 °C
• Boiling Point: 285.2 °C at 760 mmHg
• Flash Point: 127.6 °C
• PSA: 26.02000
• LogP: 3.73960
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 225.1284273
• Heavy Atom Count: 15
• Complexity: 170

Purity/Quality:

99%min ^*data from raw suppliers

5,6-Diethyl-2,3-dihydro-1H-inden-2-aminehydrochloride 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=C(C=C2CC(CC2=C1)N)CC.Cl
• Uses: 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine Hydrochloride acts as a reagent in the synthetic preparation of quinolinone compounds and it’s formulations in combination with corticosteroids for treatment of airway disorder. 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride is used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Technology Process of 5,6-diethyl-2,3-dihydro-1H-inden-2-amine Hydrochloride

There total 17 articles about 5,6-diethyl-2,3-dihydro-1H-inden-2-amine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.6%

C15H21NO → 5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride (312753-53-0)

Guidance literature:

With hydrogenchloride; In water; for 10h; Reflux;

Reference yield: 92.0%

C13H17N3 → 5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride (312753-53-0)

Guidance literature:

C₁₃H₁₇N₃; With palladium 10% on activated carbon; hydrogen; In methanol; under 3800.26 Torr; Autoclave;

With hydrogenchloride; In ethyl acetate;

Reference yield: 77.0%

5,6-diethyl-2,3-dihydro-1H-inden-2-amine (312753-70-1) → 5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride (312753-53-0)

Guidance literature:

With hydrogenchloride; In diethyl ether; under 760.051 Torr; Inert atmosphere;

DOI:10.1021/jm100068m

upstream raw materials:

N-(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide

5,6-diethyl-2,3-dihydro-1H-inden-2-amine

N-(2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide

N-(5-acetyl-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide

Downstream raw materials:

indacaterol

(R)-8-(benzyloxy)-5-[2-[(5,6-diethyl-2,3-dihydro-1H-indole-2-yl)amino]-1-hydroxyethyl]quinolin-2(1H)-one

5,6-diethyl-2,3-dihydro-1H-inden-2-amine

indacaterol maleate

Refernces

• 1、 -. "Preparation method of indacaterol intermediate". . . Retrieved 2018/11/22.
• 2、 Prashad, Mahavir,Hu, Bin,Har, Denis,Repic, Oljan,Blacklock, Thomas J.,Lohse, Olivier. "An efficient and economical synthesis of 5,6-diethyl-2,3-dihydro-1H-inden- 2-amine hydrochloride". . p. 135 - 141. Retrieved 2012/12/21.