Ethyl 4-methyl-2-[4-(2-methylpropoxy)phenyl]-1,3-thiazole-5-carboxylate

Base Information

Chemical Name:Ethyl 4-methyl-2-[4-(2-methylpropoxy)phenyl]-1,3-thiazole-5-carboxylate
CAS No.:144060-97-9
Molecular Formula:C17H21 N O3 S
Molecular Weight:319.425
Hs Code.:
DSSTox Substance ID:DTXSID201165308
Mol file:144060-97-9.mol

Synonyms:144060-97-9;3-Descyano Febuxostat Ethyl Ester;ethyl 4-methyl-2-[4-(2-methylpropoxy)phenyl]-1,3-thiazole-5-carboxylate;4-Methyl-2-[4-(2-methylpropoxy)phenyl]-5-thiazolecarboxylic Acid Ethyl Ester;Ethyl 2-(4-Isobutoxyphenyl)-4-methylthiazole-5-carboxylate;Febuxostat Descyano Ethyl Ester;SCHEMBL8867495;ethyl 2-(4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate;DTXSID201165308;DB-100993;F52701;Ethyl 4-methyl-2-[4-(2-methylpropoxy)phenyl]-5-thiazolecarboxylate

Suppliers and Price of Ethyl 4-methyl-2-[4-(2-methylpropoxy)phenyl]-1,3-thiazole-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-DescyanoFebuxostatEthylEster
1g
$ 1455.00

Total 21 raw suppliers

Chemical Property of Ethyl 4-methyl-2-[4-(2-methylpropoxy)phenyl]-1,3-thiazole-5-carboxylate

Chemical Property:

Boiling Point:438.3±55.0 °C(Predicted)
PKA:1.61±0.10(Predicted)
PSA：100.45000
Density:1.132±0.06 g/cm3(Predicted)
LogP:4.20168
XLogP3:4.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:319.12421471
Heavy Atom Count:22
Complexity:356

Purity/Quality:

97% ^*data from raw suppliers

3-DescyanoFebuxostatEthylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(N=C(S1)C2=CC=C(C=C2)OCC(C)C)C
Uses 3-Descyano Febuxostat Ethyl Ester is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.

Technology Process of Ethyl 4-methyl-2-[4-(2-methylpropoxy)phenyl]-1,3-thiazole-5-carboxylate

There total 1 articles about Ethyl 4-methyl-2-[4-(2-methylpropoxy)phenyl]-1,3-thiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%