1-<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl> hydrogen glutamate hydrochloride

Base Information

• Chemical Name: 1-<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl> hydrogen glutamate hydrochloride
• CAS No.: 123642-67-1
• Molecular Formula: C₁₅H₂₀N₂O₈*ClH
• Molecular Weight: 392.793
• Mol file: 123642-67-1.mol

Synonyms:1-<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl> hydrogen glutamate hydrochloride

Chemical Property of 1-<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl> hydrogen glutamate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl> hydrogen glutamate hydrochloride

There total 4 articles about 1-<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl> hydrogen glutamate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

1-<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl> 5-tert-butyl N-(tert-butoxycarbonyl)glutamate (123642-63-7) → 1-<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl> hydrogen glutamate hydrochloride (123642-67-1)

Guidance literature:

With hydrogenchloride; In ethyl acetate; for 1h; Ambient temperature;

DOI:10.1021/jo00292a038

Reference yield:

4',5'-dimethoxy-2'-nitroacetophenone (4101-32-0) → 1-<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl> hydrogen glutamate hydrochloride (123642-67-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 53 percent / 85percent hydrazine hydrate, glacial acetic acid / aq. ethanol / 3 h / Heating

2: 1) MnO₂ / 1) CHCl₃, 7 min, 2) 2 days

3: 58 percent / 3.5M HCl / ethyl acetate / 1 h / Ambient temperature

With hydrogenchloride; manganese(IV) oxide; hydrazine hydrate; acetic acid; In ethanol; ethyl acetate;

DOI:10.1021/jo00292a038

Reference yield:

4,5-dimethoxy-2-nitroacetophenone hydrazone (123642-61-5) → 1-<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl> hydrogen glutamate hydrochloride (123642-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) MnO₂ / 1) CHCl₃, 7 min, 2) 2 days

2: 58 percent / 3.5M HCl / ethyl acetate / 1 h / Ambient temperature

With hydrogenchloride; manganese(IV) oxide; In ethyl acetate;

DOI:10.1021/jo00292a038

upstream raw materials:

1-<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl> 5-tert-butyl N-(tert-butoxycarbonyl)glutamate

4',5'-dimethoxy-2'-nitroacetophenone

4,5-dimethoxy-2-nitroacetophenone hydrazone

1-(3,4-dimethoxyphenyl)ethanone