N-<(S)-4-<(isobutoxycarbonyl)oxy>-5-methyl-3-oxohexanoyl>-L-leucine p-chlorophenacyl ester

Base Information

Chemical Name:N-<(S)-4-<(isobutoxycarbonyl)oxy>-5-methyl-3-oxohexanoyl>-L-leucine p-chlorophenacyl ester
CAS No.:109801-76-5
Molecular Formula:C₂₆H₃₆ClNO₈
Molecular Weight:526.027
Hs Code.:

Synonyms:N-<(S)-4-<(isobutoxycarbonyl)oxy>-5-methyl-3-oxohexanoyl>-L-leucine p-chlorophenacyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<(S)-4-<(isobutoxycarbonyl)oxy>-5-methyl-3-oxohexanoyl>-L-leucine p-chlorophenacyl ester

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Technology Process of N-<(S)-4-<(isobutoxycarbonyl)oxy>-5-methyl-3-oxohexanoyl>-L-leucine p-chlorophenacyl ester

There total 2 articles about N-<(S)-4-<(isobutoxycarbonyl)oxy>-5-methyl-3-oxohexanoyl>-L-leucine p-chlorophenacyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 109801-91-4
(S)-4-<(isobutoxycarbonyl)oxy>-5-methyl-3-oxohexanoic acid ethyl thio ester

: 109801-94-7
Leu-OCpa*HCl

: 109801-76-5
N-<(S)-4-<(isobutoxycarbonyl)oxy>-5-methyl-3-oxohexanoyl>-L-leucine p-chlorophenacyl ester

Guidance literature:: With copper(l) iodide; triethylamine; In dichloromethane; Ambient temperature;
DOI:10.1021/jo00229a019

Reference yield:

: 109801-88-9
C₁₅H₂₆O₇

: 109801-76-5
N-<(S)-4-<(isobutoxycarbonyl)oxy>-5-methyl-3-oxohexanoyl>-L-leucine p-chlorophenacyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) diisopropylamine, n-BuLi / 1.) THF, -70 deg C, 30 min, 2.) THF, -65 deg C, 20 min

2: 77 percent / triethylamine, cuprous iodide / CH₂Cl₂ / Ambient temperature

With copper(l) iodide; n-butyllithium; triethylamine; diisopropylamine; In dichloromethane;
DOI:10.1021/jo00229a019

Reference yield:

: 109801-76-5
N-<(S)-4-<(isobutoxycarbonyl)oxy>-5-methyl-3-oxohexanoyl>-L-leucine p-chlorophenacyl ester

: 109801-68-5
(S)-2-((S)-4-Hydroxy-5-methyl-3-oxo-hexanoylamino)-4-methyl-pentanoic acid 2-(4-chloro-phenyl)-2-oxo-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / NaOH / diethyl ether / 1 h / Ambient temperature

2: 87 percent / KHCO₃ / acetone / 3.5 h / Heating

With sodium hydroxide; potassium hydrogencarbonate; In diethyl ether; acetone;
DOI:10.1021/jo00229a019