(R,E)-dineopentyl 2-(2-(benzyl(4-tert-butoxy-4-oxobut-2-enyl)amino)-2-(4-chlorophenyl)ethyl)malonate

Base Information

Chemical Name:(R,E)-dineopentyl 2-(2-(benzyl(4-tert-butoxy-4-oxobut-2-enyl)amino)-2-(4-chlorophenyl)ethyl)malonate
CAS No.:1379763-23-1
Molecular Formula:C₃₆H₅₀ClNO₆
Molecular Weight:628.249
Hs Code.:

Synonyms:(R,E)-dineopentyl 2-(2-(benzyl(4-tert-butoxy-4-oxobut-2-enyl)amino)-2-(4-chlorophenyl)ethyl)malonate

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Chemical Property of (R,E)-dineopentyl 2-(2-(benzyl(4-tert-butoxy-4-oxobut-2-enyl)amino)-2-(4-chlorophenyl)ethyl)malonate

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Technology Process of (R,E)-dineopentyl 2-(2-(benzyl(4-tert-butoxy-4-oxobut-2-enyl)amino)-2-(4-chlorophenyl)ethyl)malonate

There total 4 articles about (R,E)-dineopentyl 2-(2-(benzyl(4-tert-butoxy-4-oxobut-2-enyl)amino)-2-(4-chlorophenyl)ethyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1379763-08-2
dineopentyl 2-(4-chlorophenyl)cyclopropane-1,1-dicarboxylate

: 189885-29-8
tert-butyl (E)-4-(benzylamino)-2-butenoate

: 1379763-23-1
(R,E)-dineopentyl 2-(2-(benzyl(4-tert-butoxy-4-oxobut-2-enyl)amino)-2-(4-chlorophenyl)ethyl)malonate

Guidance literature:: With nickel(II) perchlorate hexahydrate; C₃₃H₂₉N₃O₃; In 1,2-dimethoxyethane; at 40 ℃; for 19h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1021/ja302691r

Reference yield: 43.0%

: 1379763-08-2
dineopentyl 2-(4-chlorophenyl)cyclopropane-1,1-dicarboxylate

: 189885-29-8
tert-butyl (E)-4-(benzylamino)-2-butenoate

: 1379763-46-8
dineopentyl 2-(4-chlorophenyl)cyclopropane-1,1-dicarboxylate

: 1379763-23-1
(R,E)-dineopentyl 2-(2-(benzyl(4-tert-butoxy-4-oxobut-2-enyl)amino)-2-(4-chlorophenyl)ethyl)malonate

Guidance literature:: With nickel(II) perchlorate hexahydrate; C₃₃H₂₉N₃O₃; In 1,2-dimethoxyethane; at 40 ℃; for 59h; optical yield given as %ee; Inert atmosphere; Molecular sieve; Resolution of racemate;
DOI:10.1021/ja302691r

Reference yield:

: 1379763-57-1
C₂₀H₂₇ClO₄

: 1379763-23-1
(R,E)-dineopentyl 2-(2-(benzyl(4-tert-butoxy-4-oxobut-2-enyl)amino)-2-(4-chlorophenyl)ethyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: nickel(II) perchlorate hexahydrate; C₃₃H₂₉N₃O₃ / 1,2-dimethoxyethane / 19 h / 40 °C / Inert atmosphere; Molecular sieve

With nickel(II) perchlorate hexahydrate; C₃₃H₂₉N₃O₃; sodium hydride; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ja302691r