(2S)-2-[(1S)-1-(2-methylbenzyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl]-2-phenylethan-1-ol

Base Information

Chemical Name:(2S)-2-[(1S)-1-(2-methylbenzyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl]-2-phenylethan-1-ol
CAS No.:929297-41-6
Molecular Formula:C₂₆H₂₉NO
Molecular Weight:371.522
Hs Code.:

Synonyms:(2S)-2-[(1S)-1-(2-methylbenzyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl]-2-phenylethan-1-ol

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Chemical Property of (2S)-2-[(1S)-1-(2-methylbenzyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl]-2-phenylethan-1-ol

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Technology Process of (2S)-2-[(1S)-1-(2-methylbenzyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl]-2-phenylethan-1-ol

There total 10 articles about (2S)-2-[(1S)-1-(2-methylbenzyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl]-2-phenylethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 929297-26-7
(3S,6S,11aR)-6-(2-methylbenzyl)-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one

: 929297-41-6
(2S)-2-[(1S)-1-(2-methylbenzyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl]-2-phenylethan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; aluminium trichloride; In tetrahydrofuran; at 0 ℃;
DOI:10.1002/ejoc.200600746

Reference yield:

: 929297-11-0
methyl (S)-2-<2-{N-[1-phenyl-2-(triisopropylsilyloxy)ethyl]carbamoylmethyl}phenyl>acetate

: 929297-41-6
(2S)-2-[(1S)-1-(2-methylbenzyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl]-2-phenylethan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 78 percent / LiBH₄ / tetrahydrofuran / 18 h / 20 °C

2.1: Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

2.2: 85 percent / NaOH / diethyl ether; CH₂Cl₂ / 0.25 h / 20 °C

3.1: 70 percent / HCl / 5 h / 20 °C

4.1: 50 percent / conc. HCl / CHCl₃ / 3 h / 0 °C

5.1: LDA / tetrahydrofuran / 1 h / 0 °C

5.2: tetrahydrofuran / 0 °C

6.1: 85 percent / AlCl₃; LiAlH₄ / tetrahydrofuran / 0 °C

With hydrogenchloride; lithium aluminium tetrahydride; lithium borohydride; aluminium trichloride; Dess-Martin periodane; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1002/ejoc.200600746

Reference yield:

: 929297-12-1
(S)-2-[2-(2-hydroxyethyl)phenyl]-N-[1-phenyl-2-(triisopropylsilyloxy)ethyl]acetamide

: 929297-41-6
(2S)-2-[(1S)-1-(2-methylbenzyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl]-2-phenylethan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

1.2: 85 percent / NaOH / diethyl ether; CH₂Cl₂ / 0.25 h / 20 °C

2.1: 70 percent / HCl / 5 h / 20 °C

3.1: 50 percent / conc. HCl / CHCl₃ / 3 h / 0 °C

4.1: LDA / tetrahydrofuran / 1 h / 0 °C

4.2: tetrahydrofuran / 0 °C

5.1: 85 percent / AlCl₃; LiAlH₄ / tetrahydrofuran / 0 °C

With hydrogenchloride; lithium aluminium tetrahydride; aluminium trichloride; Dess-Martin periodane; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1002/ejoc.200600746