But-3-enyl-[1-(2,6-dichloro-4-phenylsulfanylmethyl-pyridin-3-yl)-meth-(E)-ylidene]-amine

Base Information

• Chemical Name: But-3-enyl-[1-(2,6-dichloro-4-phenylsulfanylmethyl-pyridin-3-yl)-meth-(E)-ylidene]-amine
• CAS No.: 1027921-17-0
• Molecular Formula: C₁₇H₁₆Cl₂N₂S
• Molecular Weight: 351.299
• Mol file: 1027921-17-0.mol

Synonyms:But-3-enyl-[1-(2,6-dichloro-4-phenylsulfanylmethyl-pyridin-3-yl)-meth-(E)-ylidene]-amine

Chemical Property of But-3-enyl-[1-(2,6-dichloro-4-phenylsulfanylmethyl-pyridin-3-yl)-meth-(E)-ylidene]-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of But-3-enyl-[1-(2,6-dichloro-4-phenylsulfanylmethyl-pyridin-3-yl)-meth-(E)-ylidene]-amine

There total 2 articles about But-3-enyl-[1-(2,6-dichloro-4-phenylsulfanylmethyl-pyridin-3-yl)-meth-(E)-ylidene]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-butene-1-amine (2524-49-4) + 2,6-dichloro-4-[(phenylthio)methyl]nicotinaldehyde (441052-91-1) → But-3-enyl-[1-(2,6-dichloro-4-phenylsulfanylmethyl-pyridin-3-yl)-meth-(E)-ylidene]-amine (1027921-17-0)

Guidance literature:

3-butene-1-amine; 2,6-dichloro-4-[(phenylthio)methyl]nicotinaldehyde; In benzene; at 20 ℃; for 2h;

With sodium sulfate; In benzene; at 20 ℃; for 2h;

DOI:10.1021/jm049707c

Reference yield:

2,6-dichloro-4-[(phenylthio)methyl]nicotinonitrile (441052-90-0) → But-3-enyl-[1-(2,6-dichloro-4-phenylsulfanylmethyl-pyridin-3-yl)-meth-(E)-ylidene]-amine (1027921-17-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 62 percent / DIBAL-H / CH₂Cl₂; toluene / -78 - 20 °C

2.1: benzene / 2 h / 20 °C

2.2: Na₂SO₄ / benzene / 2 h / 20 °C

With diisobutylaluminium hydride; In dichloromethane; toluene; benzene;

DOI:10.1021/jm049707c

Reference yield:

But-3-enyl-[1-(2,6-dichloro-4-phenylsulfanylmethyl-pyridin-3-yl)-meth-(E)-ylidene]-amine (1027921-17-0) → 7,9-dichloro-5-phenylsulfanyl-2,3,3a,4,5,9b-hexahydropyrrolo[3,2-h]isoquinoline

Guidance literature:

Multi-step reaction with 2 steps

1.1: 70 mg / diisopropylethylamine / xylene / 3 h / Heating

2.1: NaI; trimethylsilyl chloride / acetonitrile / 2 h / Heating

2.2: 70 percent / MeOH / acetonitrile / 0.25 h / 20 °C

With chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine; sodium iodide; In acetonitrile; xylene; 1.1: intramolecular Diels-Alder reaction;

DOI:10.1021/jm049707c

upstream raw materials:

3-butene-1-amine

2,6-dichloro-4-[(phenylthio)methyl]nicotinaldehyde

2,6-dichloro-4-[(phenylthio)methyl]nicotinonitrile