Technology Process of 2-(3-methoxyphenoxy)benzyl chloride
There total 2 articles about 2-(3-methoxyphenoxy)benzyl chloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
thionyl chloride;
In
toluene;
at 80 ℃;
for 1h;
DOI:10.1021/jm00362a009
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 97 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 4 h / Heating
2: thionyl chloride / toluene / 1 h / 80 °C
With
lithium aluminium tetrahydride; thionyl chloride;
In
tetrahydrofuran; diethyl ether; toluene;
DOI:10.1021/jm00362a009
- Guidance literature:
-
Multi-step reaction with 8 steps
1: ethanol; H2O / 12 h / Heating
2: 76 percent / aq. KOH / ethanol / 3 h / Heating
3: 83 percent / polyphosphoric acid / toluene / 4 h / Heating
4: 95 percent / tetrabutylammonium hydrogen sulfate, aq. NaOH / CH2Cl2 / 0.5 h
5: 58 percent / pyridine hydrochloride / 0.5 h / 210 °C
6: 90 percent / K2CO3 / acetone / 3 h / Heating
7: 1.) BuLi / 1.) THF, -70 deg C, 1 h, 2.) THF, RT, 18 h
8: conc. HCl / ethanol / 1 h / Heating
With
hydrogenchloride; potassium hydroxide; sodium hydroxide; n-butyllithium; PPA; tetra(n-butyl)ammonium hydrogensulfate; pyridine hydrochloride; potassium carbonate;
In
ethanol; dichloromethane; water; acetone; toluene;
DOI:10.1021/jm00362a009
