N⁽³⁾-(2-trimethylsilyl)ethoxymethyl-5'-O-tert-butyldimethylsilyl-3'-O-tert-butyldiphenylsilylthymidine

Base Information

• Chemical Name: N⁽³⁾-(2-trimethylsilyl)ethoxymethyl-5'-O-tert-butyldimethylsilyl-3'-O-tert-butyldiphenylsilylthymidine
• CAS No.: 1072452-74-4
• Molecular Formula: C₃₈H₆₀N₂O₆Si₃
• Molecular Weight: 725.161

Synonyms:N⁽³⁾-(2-trimethylsilyl)ethoxymethyl-5'-O-tert-butyldimethylsilyl-3'-O-tert-butyldiphenylsilylthymidine

Chemical Property of N⁽³⁾-(2-trimethylsilyl)ethoxymethyl-5'-O-tert-butyldimethylsilyl-3'-O-tert-butyldiphenylsilylthymidine

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Technology Process of N⁽³⁾-(2-trimethylsilyl)ethoxymethyl-5'-O-tert-butyldimethylsilyl-3'-O-tert-butyldiphenylsilylthymidine

There total 1 articles about N⁽³⁾-(2-trimethylsilyl)ethoxymethyl-5'-O-tert-butyldimethylsilyl-3'-O-tert-butyldiphenylsilylthymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) + 5'-O-(tert-butyldimethylsilyl)-3'-O-(tert-butyldiphenylsilyl)thymidine (166758-13-0) → N(3)-(2-trimethylsilyl)ethoxymethyl-5'-O-tert-butyldimethylsilyl-3'-O-tert-butyldiphenylsilylthymidine (1072452-74-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 72h;

DOI:10.1039/b810008j

Reference yield: 57.0%

N(3)-(2-trimethylsilyl)ethoxymethyl-5'-O-tert-butyldimethylsilyl-3'-O-tert-butyldiphenylsilylthymidine (1072452-74-4) → N(3)-2-(trimethylsilyl)ethoxymethyl-5'-O-tert-butyldimethylsilyl-3'-O-tert-butyldiphenylsilyl-5-bromomethyl-2'-deoxyuridine (1072452-73-3)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; at 70 ℃; for 0.5h;

DOI:10.1039/b810008j

upstream raw materials:

(2-trimethylethylsilylethoxy)methyl chloride

5'-O-(tert-butyldimethylsilyl)-3'-O-(tert-butyldiphenylsilyl)thymidine

Downstream raw materials:

N⁽³⁾-2-(trimethylsilyl)ethoxymethyl-5'-O-tert-butyldimethylsilyl-3'-O-tert-butyldiphenylsilyl-5-bromomethyl-2'-deoxyuridine

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