5'-O-dimethoxytrityl-4-(S-pivaloyloxymethyl)-4-thiothymidin-3'-yl hydrogenphosphonate

Base Information

Chemical Name:5'-O-dimethoxytrityl-4-(S-pivaloyloxymethyl)-4-thiothymidin-3'-yl hydrogenphosphonate
CAS No.:139887-91-5
Molecular Formula:C₃₇H₄₃N₂O₁₀PS
Molecular Weight:738.796
Hs Code.:

Synonyms:5'-O-dimethoxytrityl-4-(S-pivaloyloxymethyl)-4-thiothymidin-3'-yl hydrogenphosphonate

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Chemical Property of 5'-O-dimethoxytrityl-4-(S-pivaloyloxymethyl)-4-thiothymidin-3'-yl hydrogenphosphonate

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Technology Process of 5'-O-dimethoxytrityl-4-(S-pivaloyloxymethyl)-4-thiothymidin-3'-yl hydrogenphosphonate

There total 5 articles about 5'-O-dimethoxytrityl-4-(S-pivaloyloxymethyl)-4-thiothymidin-3'-yl hydrogenphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 139887-85-7
5'-O-dimethoxytrityl-4-S-pivaloyloxymethyl-4-thiothymidine

: 139887-91-5
5'-O-dimethoxytrityl-4-(S-pivaloyloxymethyl)-4-thiothymidin-3'-yl hydrogenphosphonate

Guidance literature:: With 1H-imidazole; N-ethyl-N,N-diisopropylamine; phosphorus trichloride; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 7236-57-9
4-thiothymidine

: 139887-91-5
5'-O-dimethoxytrityl-4-(S-pivaloyloxymethyl)-4-thiothymidin-3'-yl hydrogenphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 68.5 percent / K₂CO₃ / acetone / 18 h / Ambient temperature

2: 55.4 percent / pyridine / Ambient temperature

3: 77 percent / imidazole, PCl₃, diisopropylethylamine / CH₂Cl₂ / 1 h / 0 °C

With pyridine; 1H-imidazole; potassium carbonate; N-ethyl-N,N-diisopropylamine; phosphorus trichloride; In dichloromethane; acetone;

Reference yield:

: 18997-19-8
Chloromethyl pivalate

: 139887-91-5
5'-O-dimethoxytrityl-4-(S-pivaloyloxymethyl)-4-thiothymidin-3'-yl hydrogenphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 68.5 percent / K₂CO₃ / acetone / 18 h / Ambient temperature

2: 55.4 percent / pyridine / Ambient temperature

3: 77 percent / imidazole, PCl₃, diisopropylethylamine / CH₂Cl₂ / 1 h / 0 °C

With pyridine; 1H-imidazole; potassium carbonate; N-ethyl-N,N-diisopropylamine; phosphorus trichloride; In dichloromethane; acetone;