8-((R)-chroman-4-yl)-1-phenyl-3-((S)-1-tosylpyrrolidine-2-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one

Base Information

Chemical Name:8-((R)-chroman-4-yl)-1-phenyl-3-((S)-1-tosylpyrrolidine-2-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one
CAS No.:1630952-73-6
Molecular Formula:C₃₄H₃₈N₄O₅S
Molecular Weight:614.766
Hs Code.:

Synonyms:8-((R)-chroman-4-yl)-1-phenyl-3-((S)-1-tosylpyrrolidine-2-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one

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Chemical Property of 8-((R)-chroman-4-yl)-1-phenyl-3-((S)-1-tosylpyrrolidine-2-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one

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Technology Process of 8-((R)-chroman-4-yl)-1-phenyl-3-((S)-1-tosylpyrrolidine-2-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one

There total 8 articles about 8-((R)-chroman-4-yl)-1-phenyl-3-((S)-1-tosylpyrrolidine-2-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 8-(chroman-4-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

: 54731-09-8,118776-39-9
N-tosyl-L-prolyl chloride

: 1630952-74-7
8-((S)-chroman-4-yl)-1-phenyl-3-((S)-1-tosylpyrrolidine-2-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one

: 1630952-73-6
8-((R)-chroman-4-yl)-1-phenyl-3-((S)-1-tosylpyrrolidine-2-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; Inert atmosphere; Reflux;
DOI:10.1039/c4md00082j

Reference yield:

: 118-93-4,104809-67-8
o-hydroxyacetophenone

: 1630952-73-6
8-((R)-chroman-4-yl)-1-phenyl-3-((S)-1-tosylpyrrolidine-2-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: pyrrolidine / ethanol / 24 h / Inert atmosphere; Reflux

2: sodium tetrahydroborate / methanol / 0.5 h / 0 - 20 °C / Inert atmosphere

3: thionyl chloride / dichloromethane / 1 h / 20 °C / Inert atmosphere; Cooling with ice

4: potassium iodide; potassium carbonate / acetonitrile / 4 h / Inert atmosphere; Reflux

5: triethylamine / dichloromethane / 0 °C / Inert atmosphere; Reflux

With pyrrolidine; sodium tetrahydroborate; thionyl chloride; potassium carbonate; triethylamine; potassium iodide; In methanol; ethanol; dichloromethane; acetonitrile;
DOI:10.1039/c4md00082j

Reference yield:

: 491-37-2
2,3-dihydro-4H-1-benzopyran-4-one

: 1630952-73-6
8-((R)-chroman-4-yl)-1-phenyl-3-((S)-1-tosylpyrrolidine-2-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / methanol / 0.5 h / 0 - 20 °C / Inert atmosphere

2: thionyl chloride / dichloromethane / 1 h / 20 °C / Inert atmosphere; Cooling with ice

3: potassium iodide; potassium carbonate / acetonitrile / 4 h / Inert atmosphere; Reflux

4: triethylamine / dichloromethane / 0 °C / Inert atmosphere; Reflux

With sodium tetrahydroborate; thionyl chloride; potassium carbonate; triethylamine; potassium iodide; In methanol; dichloromethane; acetonitrile;
DOI:10.1039/c4md00082j