benzyl (R,R,R)-N(1')-methyl-N(2')-(3'-[N-benzyl-N-(α-methylbenzyl)amino]-4''-[2''',2'''-dimethyl-N(3''')-tert-butoxycarbonyl-1''',3'''-oxazolidin-5'''-yl]butanoyl)hydrazinylethanoate

Base Information

Chemical Name:benzyl (R,R,R)-N(1')-methyl-N(2')-(3'-[N-benzyl-N-(α-methylbenzyl)amino]-4''-[2''',2'''-dimethyl-N(3''')-tert-butoxycarbonyl-1''',3'''-oxazolidin-5'''-yl]butanoyl)hydrazinylethanoate
CAS No.:181772-78-1
Molecular Formula:C₃₉H₅₂N₄O₆
Molecular Weight:672.865
Hs Code.:

benzyl (R,R,R)-N(1')-methyl-N(2')-(3'-[N-benzyl-N-(α-methylbenzyl)amino]-4''-[2''',2'''-dimethyl-N(3''')-tert-butoxycarbonyl-1''',3'''-oxazolidin-5'''-yl]butanoyl)hydrazinylethanoate

Synonyms:benzyl (R,R,R)-N(1')-methyl-N(2')-(3'-[N-benzyl-N-(α-methylbenzyl)amino]-4''-[2''',2'''-dimethyl-N(3''')-tert-butoxycarbonyl-1''',3'''-oxazolidin-5'''-yl]butanoyl)hydrazinylethanoate

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Chemical Property of benzyl (R,R,R)-N(1')-methyl-N(2')-(3'-[N-benzyl-N-(α-methylbenzyl)amino]-4''-[2''',2'''-dimethyl-N(3''')-tert-butoxycarbonyl-1''',3'''-oxazolidin-5'''-yl]butanoyl)hydrazinylethanoate

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Technology Process of benzyl (R,R,R)-N(1')-methyl-N(2')-(3'-[N-benzyl-N-(α-methylbenzyl)amino]-4''-[2''',2'''-dimethyl-N(3''')-tert-butoxycarbonyl-1''',3'''-oxazolidin-5'''-yl]butanoyl)hydrazinylethanoate

There total 9 articles about benzyl (R,R,R)-N(1')-methyl-N(2')-(3'-[N-benzyl-N-(α-methylbenzyl)amino]-4''-[2''',2'''-dimethyl-N(3''')-tert-butoxycarbonyl-1''',3'''-oxazolidin-5'''-yl]butanoyl)hydrazinylethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 55501-34-3
Benzyl 2-(N-methylhydrazino)acetate p-toluenesulfonic acid salt

: 181772-92-9
(R)-5-{(R)-2-[Benzyl-((R)-1-phenyl-ethyl)-amino]-3-carboxy-propyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 181772-78-1
benzyl (R,R,R)-N(1')-methyl-N(2')-(3'-[N-benzyl-N-(α-methylbenzyl)amino]-4''-[2''',2'''-dimethyl-N(3''')-tert-butoxycarbonyl-1''',3'''-oxazolidin-5'''-yl]butanoyl)hydrazinylethanoate

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; Ambient temperature;
DOI:10.1016/0957-4166(96)00230-3

Reference yield:

: C₃₂H₄₄N₂O₇

: 55501-34-3
Benzyl 2-(N-methylhydrazino)acetate p-toluenesulfonic acid salt

: 181772-78-1
benzyl (R,R,R)-N(1')-methyl-N(2')-(3'-[N-benzyl-N-(α-methylbenzyl)amino]-4''-[2''',2'''-dimethyl-N(3''')-tert-butoxycarbonyl-1''',3'''-oxazolidin-5'''-yl]butanoyl)hydrazinylethanoate

Guidance literature:: With triethylamine; In dichloromethane; at -15 - 0 ℃; for 0.583333h; Inert atmosphere;
DOI:10.1016/j.tet.2010.10.067

Reference yield:

: 181772-51-0
ethyl (3R)-4-(tert-butyloxycarbonyl)amino-3-hydroxybutanoate

: 181772-78-1
benzyl (R,R,R)-N(1')-methyl-N(2')-(3'-[N-benzyl-N-(α-methylbenzyl)amino]-4''-[2''',2'''-dimethyl-N(3''')-tert-butoxycarbonyl-1''',3'''-oxazolidin-5'''-yl]butanoyl)hydrazinylethanoate

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / CSA / acetone

2: 97 percent / sodium bis(2-methoxyethoxy)aluminium hydride

3: 1.) oxalyl chloride, DMSO, 2.) iPr₂NEt

4: toluene / 60 °C

5: 85 percent / tetrahydrofuran / -78 °C

6: 82 percent / aq. LiOH / methanol; tetrahydrofuran

7: 96 percent / DCC, Et₃N, HOBt / Ambient temperature

With lithium hydroxide; oxalyl dichloride; camphor-10-sulfonic acid; benzotriazol-1-ol; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; acetone; toluene;
DOI:10.1016/0957-4166(96)00230-3