4-HYDROXYPHTHALIC ANHYDRIDE

Base Information

• Chemical Name: 4-HYDROXYPHTHALIC ANHYDRIDE
• CAS No.: 27550-59-0
• Molecular Formula: C8H4O4
• Molecular Weight: 164.117
• Hs Code.: 2932999099
• Mol file: 27550-59-0.mol

Synonyms:4-HYDROXYPHTHALIC ANHYDRIDE;5-hydroxyisobenzofuran-1,3-dione

Chemical Property of 4-HYDROXYPHTHALIC ANHYDRIDE

Chemical Property:

• Melting Point: 171-173 °C(Solv: acetic acid (64-19-7))
• Boiling Point: 407.8 °C at 760 mmHg
• PKA: 6.52±0.20(Predicted)
• Flash Point: 179.4 °C
• PSA: 63.60000
• Density: 1.625 g/cm³
• LogP: 0.70280
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Hydroxyisobenzofuran-1,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXYPHTHALIC ANHYDRIDE

There total 8 articles about 4-HYDROXYPHTHALIC ANHYDRIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-hydroxyphthalic acid (610-35-5) → 4-hydroxyphthalic anhydride (27550-59-0)

Guidance literature:

Heating;

DOI:10.1016/j.bmcl.2005.07.048

Reference yield: 84.6%

4-aminophthalic acid (5434-21-9) → 4-hydroxyphthalic anhydride (27550-59-0)

Guidance literature:

With sulfuric acid; sodium nitrite; In water; at 0 - 165 ℃; for 3h; Temperature;

Reference yield:

4-Nitrophthalonitrile (31643-49-9) → 4-hydroxyphthalic anhydride (27550-59-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium nitrite; potassium carbonate / dimethyl sulfoxide / 3 h / 160 °C / Inert atmosphere

2: potassium hydroxide / water / 90 h / Reflux

3: Heating

With potassium carbonate; potassium hydroxide; sodium nitrite; In water; dimethyl sulfoxide;

DOI:10.1039/c5ra16574a

upstream raw materials:

4-hydroxyphthalic acid

Diethyl 4-hydroxyphthalate

diethyl 4-aminophthalate

2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione

Downstream raw materials:

4-acetoxyphthalic anhydride

(Z)-3-(1-butylidene)-5-hydroxyphthalide

Refernces

• 1、 Zhou, Yu,Chen, Guofei,Wang, Wei,Wei, Lihong,Zhang, Qiuju,Song, Liping,Fang, Xingzhong. "Synthesis and characterization of transparent polyimides derived from ester-containing dianhydrides with different electron affinities". . p. 79207 - 79215. Retrieved 2015.
• 2、 -. "A hydroxy benzoic anhydride preparation method". Page/Page column 0041; 0044-0046. . Retrieved 2017/08/25.