methyl (2S,3R)-2-[N-(benzyloxy)carbonyl-N-methylamino]-3-[(3-fluoro-4-nitro)phenyl]-3-hydroxypropionate

Base Information

Chemical Name:methyl (2S,3R)-2-[N-(benzyloxy)carbonyl-N-methylamino]-3-[(3-fluoro-4-nitro)phenyl]-3-hydroxypropionate
CAS No.:912341-72-1
Molecular Formula:C₁₉H₁₉FN₂O₇
Molecular Weight:406.367
Hs Code.:

Synonyms:methyl (2S,3R)-2-[N-(benzyloxy)carbonyl-N-methylamino]-3-[(3-fluoro-4-nitro)phenyl]-3-hydroxypropionate

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Chemical Property of methyl (2S,3R)-2-[N-(benzyloxy)carbonyl-N-methylamino]-3-[(3-fluoro-4-nitro)phenyl]-3-hydroxypropionate

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Technology Process of methyl (2S,3R)-2-[N-(benzyloxy)carbonyl-N-methylamino]-3-[(3-fluoro-4-nitro)phenyl]-3-hydroxypropionate

There total 3 articles about methyl (2S,3R)-2-[N-(benzyloxy)carbonyl-N-methylamino]-3-[(3-fluoro-4-nitro)phenyl]-3-hydroxypropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 912341-89-0
methyl (2S,3R)-3-[(3-fluoro-4-nitro)phenyl]-3-hydroxy-2-(N-methylamino)propionate

: 501-53-1,94274-21-2
benzyl chloroformate

: 912341-72-1
methyl (2S,3R)-2-[N-(benzyloxy)carbonyl-N-methylamino]-3-[(3-fluoro-4-nitro)phenyl]-3-hydroxypropionate

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; water; at 0 - 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2006.06.071

Reference yield:

: 912341-88-9
(4S,5R)-5-(3-Fluoro-4-nitro-phenyl)-oxazolidine-4-carboxylic acid methyl ester

: 912341-72-1
methyl (2S,3R)-2-[N-(benzyloxy)carbonyl-N-methylamino]-3-[(3-fluoro-4-nitro)phenyl]-3-hydroxypropionate

Guidance literature:: Multi-step reaction with 2 steps

1: 0.204 g / TFA; Et₃SiH / CH₂Cl₂ / 20 °C

2: 100 percent / NaHCO₃ / dioxane; H₂O / 2 h / 0 - 20 °C

With triethylsilane; sodium hydrogencarbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.bmcl.2006.06.071

Reference yield:

: 376392-70-0
methyl (2S,3R)-2-amino-3-hydroxy-[(3-fluoro-4-nitro)phenyl]propionate

: 912341-72-1
methyl (2S,3R)-2-[N-(benzyloxy)carbonyl-N-methylamino]-3-[(3-fluoro-4-nitro)phenyl]-3-hydroxypropionate

Guidance literature:: Multi-step reaction with 3 steps

1: H₂O / 1 h / 20 °C

2: 0.204 g / TFA; Et₃SiH / CH₂Cl₂ / 20 °C

3: 100 percent / NaHCO₃ / dioxane; H₂O / 2 h / 0 - 20 °C

With triethylsilane; sodium hydrogencarbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.bmcl.2006.06.071